General Information of HIF (ID: HIFM0037)
HIF Name	Monocyte differentiation antigen CD14
HIF Synonym(s)	CD14 molecule
HIF Classification	T-cell receptor (TCR)
Description	CD14 is a lipopolysaccharide-binding protein, which functions as an endotoxin receptor.				[1]
Pathway	Acute myeloid leukemia (hsa05221 )
	Amoebiasis (hsa05146 )
	Hematopoietic cell lineage (hsa04640 )
	Legionellosis (hsa05134 )
	MAPK signaling pathway (hsa04010 )
	NF-kappa B signaling pathway (hsa04064 )
	Pertussis (hsa05133 )
	Phagosome (hsa04145 )
	Salmonella infection (hsa05132 )
	Shigellosis (hsa05131 )
	Toll-like receptor signaling pathway (hsa04620 )
	Transcriptional misregulation in cancer (hsa05202 )
	Tuberculosis (hsa05152 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	CD14_HUMAN

Microbe Species (MIC) Regulated by This HIF
Bifidobacterium breve (actinobacteria)			MIC00210
Description	Probiotics(Bifidobacterium breve) can inhibit the binding of lipopolysaccharides to the CD14 receptor.				[2]
Eubacterium rectale (firmicutes)			MIC00578
Description	Microbiota composition improved significantly decreased Eubacterium rectale cluster and a reduction of soluble CD14 (sCD14).				[3]
Lactobacillus casei (firmicutes)			MIC00707
Description	Probiotics(Lactobacillus casei) can inhibit the binding of lipopolysaccharides to the CD14 receptor.				[2]
Lactobacillus fermentum (firmicutes)			MIC00714
Description	Probiotics(Lactobacillus fermentum) can inhibit the binding of lipopolysaccharides to the CD14 receptor.				[2]
Lactobacillus plantarum (firmicutes)			MIC00730
Description	Probiotics(Lactobacillus plantarum) can inhibit the binding of lipopolysaccharides to the CD14 receptor.				[2]
Lactobacillus salivarius (firmicutes)			MIC00735
Description	Probiotics(Lactobacillus salivarius) can inhibit the binding of lipopolysaccharides to the CD14 receptor.				[2]
Legionella pneumophila (gamma-proteobacteria)			MIC00751
Description	Legionella pneumophila induced the expression of CD14 via TLR2.				[4]

References
1	Role of CD14 in host protection against infections and in metabolism regulation.Front Cell Infect Microbiol. 2013 Jul 24;3:32. doi: 10.3389/fcimb.2013.00032. eCollection 2013.
2	Probiotics importance and their immunomodulatory properties. J Cell Physiol. 2019 Jun;234(6):8008-8018. doi: 10.1002/jcp.27559. Epub 2018 Oct 14.
3	Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: results of the "COPA" pilot randomized trial. Mucosal Immunol. 2011 Sep;4(5):554-63. doi: 10.1038/mi.2011.15. Epub 2011 Apr 27.
4	Innate immunity to legionella pneumophila. Front Microbiol. 2011 May 16;2:109. doi: 10.3389/fmicb.2011.00109. eCollection 2011.

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