General Information of HIF (ID: HIFM0262)
HIF Name	Interferon-1
HIF Synonym(s)	interferon I
HIF Classification	Cytokine (Cyt)
Description	Type I interferons (IFN-I) were first described over 50 years ago as factors produced by cells that interfere with virus replication and promote an antiviral state. Innate and adaptive immune responses to viruses are also greatly influenced by IFN-I.				[1]

Microbe Species (MIC) Regulated by This HIF
Legionella pneumophila (gamma-proteobacteria)			MIC00751
Description	Type I IFN can in response to Legionella pneumophila infection.				[2]
Listeria monocytogenes (firmicutes)			MIC00771
Description	At the species level, Listeria monocytogenes is associated with type I interferons.				[3]

References
1	Type I interferons: diversity of sources, production pathways and effects on immune responses.Curr Opin Virol. 2011 Dec;1(6):463-75. doi: 10.1016/j.coviro.2011.10.026. Epub 2011 Nov 25.
2	Innate immunity to legionella pneumophila. Front Microbiol. 2011 May 16;2:109. doi: 10.3389/fmicb.2011.00109. eCollection 2011.
3	HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes. PLoS Pathog. 2017 Dec 27;13(12):e1006799. doi: 10.1371/journal.ppat.1006799. eCollection 2017 Dec.

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