Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0184)
HIF Name
Nucleotide-binding oligomerization domain-containing protein 1
HIF Synonym(s)
nucleotide binding oligomerization domain containing 1, NOD1, CARD4, CLR7.1
HIF Classification
Nod-like receptor (NLR)
Description NLRC1 is a member of the Nucleotide oligomerization domain (NOD)-like receptor (NLR)family NLRC. [1]
Pfam Caspase recruitment domain (PF00619 )
Leucine Rich repeat (PF13516 )
NACHT domain (PF05729 )
NLRC4 helical domain HD2 (PF17776 )
NOD2 winged helix domain (PF17779 )
Pathway Epithelial cell signaling in Helicobacter pylori infection (hsa05120 )
NOD-like receptor signaling pathway (hsa04621 )
Pertussis (hsa05133 )
Salmonella infection (hsa05132 )
Shigellosis (hsa05131 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
NOD1_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Chlamydia pneumoniae (chlamydias) MIC00350
             Description Intracellular receptors NOD1,which recognize peptidoglycan components, is important players in the immune response to Chlamydophila pneumoniae. [2]
         Clostridioides difficile (firmicutes) MIC00396
             Description Clostridium difficile toxins can activate both surface and intracellular innate immune sensors, such as the NOD1 signaling pathways. [3]
         Legionella pneumophila (gamma-proteobacteria) MIC00751
             Description The NOD1 signaling can in response to Legionella pneumophila infection. [4]
References
1 Function of Nod-like receptors in microbial recognition and host defense.Immunol Rev. 2009 Jan;227(1):106-28. doi: 10.1111/j.1600-065X.2008.00734.x.
2 Chlamydia pneumoniae Infection and Inflammatory Diseases. For Immunopathol Dis Therap. 2016;7(3-4):237-254. doi: 10.1615/ForumImmunDisTher.2017020161.
3 Immune responses to Clostridium difficile infection.Trends Mol Med. 2012 Nov;18(11):658-66. doi: 10.1016/j.molmed.2012.09.005. Epub 2012 Oct 16.
4 Innate immunity to legionella pneumophila. Front Microbiol. 2011 May 16;2:109. doi: 10.3389/fmicb.2011.00109. eCollection 2011.

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