General Information of MIC (ID: MIC00576)
MIC Name	Eubacterium limosum (firmicutes)
MIC Synonyms	Bacteroides limosus
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Eubacteriaceae Genus: Eubacterium Species: Eubacterium limosum
Oxygen Sensitivity	Obligate anaerobe
Microbial Metabolism	Saccharolytic; Fermentative
Gram	Positive
Host Relationship	Commensal
Genome Size (bp)	4150332
No. of Coding Genes	3805
No. of Non-Coding Genes	76
No. of Small Non-Coding Genes	76
No. of Gene Transcripts	3881
No. of Base Pairs	4150332
Description	Eubacterium limosum is an obligate anaerobic, Gram positive, nonmotile type species of the genus Eubacterium.
External Links	Taxonomy ID	1736
	Genome Assembly ID	ASM148172v1
	GOLD Organism ID	Go0119287
Disease Relevance
Graft-versus-host disease  [ICD-11: 4B24]
Description	Higher abundance of a bacterial group composed mostly of Eubacterium limosum in the validation set was associated with a decreased risk of relapse/progression of Graft-versus-host disease.				[1]

Host Immune Factors (HIFs)
Interferon-13
HIF ID	HIFM0132	HIF Info	Class	Cytokine (Cyt)
Description	A decreased IL-13 release after Eubacterium limosum stimulation.				[2]
Interferon-6
HIF ID	HIFM0151	HIF Info	Class	Cytokine (Cyt)
Description	Eubacterium limosum could produce the IL-6 expression.				[3]
Tumor necrosis factor
HIF ID	HIFM0226	HIF Info	Class	Cytokine (Cyt)
Description	The abundance of Eubacterium limosum is associated with TNF-Alpha.				[3]
Toll-like receptor 4
HIF ID	HIFM0219	HIF Info	Class	Toll-like receptor (TLR)
Description	Eubacterium limosum can produce butyrate on the mucosal innate immune response via activate TLR4 system.				[3]

Environmental Factor(s)
Disbiome ID			477
gutMDisorder ID			gm0315

References
1	Intestinal Microbiota and Relapse After Hematopoietic-Cell Transplantation. J Clin Oncol. 2017 May 20;35(15):1650-1659. doi: 10.1200/JCO.2016.70.3348. Epub 2017 Mar 15.
2	Cytokine Response after Stimulation with Key Commensal Bacteria Differ in Post-Infectious Irritable Bowel Syndrome (PI-IBS) Patients Compared to Healthy Controls. PLoS One. 2015 Sep 14;10(9):e0134836. doi: 10.1371/journal.pone.0134836. eCollection 2015.
3	Eubacterium limosum ameliorates experimental colitis and metabolite of microbe attenuates colonic inflammatory action with increase of mucosal integrity. World J Gastroenterol. 2006 Feb 21;12(7):1071-7. doi: 10.3748/wjg.v12.i7.1071.

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