General Information of HIF (ID: HIFM0132)
HIF Name	Interferon-13
HIF Synonym(s)	interleukin 13, IL13, P600, IL-13
HIF Classification	Cytokine (Cyt)
Molecular Function	Cytokine
Description	IL-13: A gene on chromosome 5q31 that encodes interleukin-13, an immunoregulatory cytokine produced primarily by activated Th2 cells which is involved in B-cell maturation and differentiation.				[1]
Pfam	Interleukin-13 (PF03487 )
Pathway	Asthma (hsa05310 )
	Cytokine-cytokine receptor interaction (hsa04060 )
	Fc epsilon RI signaling pathway (hsa04664 )
	IL-17 signaling pathway (hsa04657 )
	Inflammatory bowel disease (IBD) (hsa05321 )
	JAK-STAT signaling pathway (hsa04630 )
	Pathways in cancer (hsa05200 )
	Th1 and Th2 cell differentiation (hsa04658 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	IL13_HUMAN

Microbe Species (MIC) Regulated by This HIF
Clostridium leptum (firmicutes)			MIC00402
Description	Early-life Clostridium leptum exposure induced an immunosuppressive environment in the lung concurrent with increased Treg cells, resulting in the inhibition of Th2 cell responses,which secreted the cytokine IL-13.				[2]
Escherichia coli (enterobacteria)			MIC00516
Description	Escherichia coli increased the IL-13 expression.				[3]
Eubacterium limosum (firmicutes)			MIC00576
Description	A decreased IL-13 release after Eubacterium limosum stimulation.				[4]
Gardnerella vaginalis (actinobacteria)			MIC00626
Description	IL13 exhibited a correlation with the altered vaginal milieu microbe Gardnerella vaginalis(p=0.184).				[5]

References
1	Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes.Front Immunol. 2018 Jun 7;9:888. doi: 10.3389/fimmu.2018.00888. eCollection 2018.
2	Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression. PLoS One. 2015 Nov 13;10(11):e0141717. doi: 10.1371/journal.pone.0141717. eCollection 2015.
3	Dexmedetomidine alleviates sleep-restriction-mediated exaggeration of postoperative immunosuppression via splenic TFF2 in aged mice. Aging (Albany NY). 2020 Mar 22;12(6):5318-5335. doi: 10.18632/aging.102952. Epub 2020 Mar 22.
4	Cytokine Response after Stimulation with Key Commensal Bacteria Differ in Post-Infectious Irritable Bowel Syndrome (PI-IBS) Patients Compared to Healthy Controls. PLoS One. 2015 Sep 14;10(9):e0134836. doi: 10.1371/journal.pone.0134836. eCollection 2015.
5	In vivo microbiome and associated immune markers: New insights into the pathogenesis of vaginal dysbiosis. Sci Rep. 2018 Feb 2;8(1):2307. doi: 10.1038/s41598-018-20649-x.

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