Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00136)
MIC Name Bacillus subtilis (firmicutes)
MIC Synonyms Vibrio subtilis
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Bacillaceae
Genus: Bacillus
Species: Bacillus subtilis
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Respiration or Fermentation of carbohydrates and central metabolism intermediates
Gram Positive
Host Relationship Probiotic
Genome Size (bp) 4215606
No. of Coding Genes 3940
No. of Non-Coding Genes 121
No. of Small Non-Coding Genes 121
No. of Gene Transcripts 4061
No. of Base Pairs 4263792
Description Bacillus subtilis, also known as the hay bacillus or grass bacillus, is a facultative anaerobic, Gram-positive, catalase-positive bacterium, found in soil and the gastrointestinal tract of ruminants and humans.
External Links Taxonomy ID
1423
Genome Assembly ID
ASM69118v1
GOLD Organism ID
Go0527396
Host Immune Factors (HIFs)
          Liver-expressed antimicrobial peptide 1
             HIF ID HIFM0111 HIF Info       Class Antimicrobial peptide (AMP)
             Description The IC50 values (Hepcidin concentration at which 50% of the bacterial growth is inhibited) for Pdp11, 51M6, Bacillus subtilis of 2.20, 14.61, 11.41 and 18.66M, respectively. [1]
          Regenerating islet-derived protein 3-beta
             HIF ID HIFM0197 HIF Info       Class Antimicrobial peptide (AMP)
             Description The recombinant purified RegIII had bactericidal activity against Bacillus subtilis and the effective doses for bactericidal activity were below 2.5 M. [2]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Bacillus subtilis could higher expression level of IL-6. [3]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Bacillus subtilis is associated with the tumour necrosis factor-alpha. [3]
          T cells
             HIF ID HIFC0002 HIF Info       Class T cells (TCs)
             Description Stimulation of T lymphocytes was markedly enhanced during Bacillus subtilis infection. [3]
          Toll-like receptor 2
             HIF ID HIFM0217 HIF Info       Class Toll-like receptor (TLR)
             Description Bacillus subtilis coincubation of cultured cells with either spores (3*106) or vegetative cells (3*106) showed a clear temporal increase in expression of TLR2(p<0.05). [3]
          Toll-like receptor 4
             HIF ID HIFM0219 HIF Info       Class Toll-like receptor (TLR)
             Description Bacillus subtilis can stimulate the expression of TLR2 and TLR4. [3]
Environmental Factor(s)
             Disbiome ID
      125
             gutMDisorder ID
      gm0067
             aBiofilm Organism
      Bacillus subtilis
References
1 Impact of Tilapia hepcidin 2-3 dietary supplementation on the gut microbiota profile and immunomodulation in the grouper (Epinephelus lanceolatus).Sci Rep. 2019 Dec 13;9(1):19047. doi: 10.1038/s41598-019-55509-9.
2 Salmonella-induced mucosal lectin RegIII kills competing gut microbiota.PLoS One. 2011;6(6):e20749. doi: 10.1371/journal.pone.0020749. Epub 2011 Jun 9.
3 Immunostimulatory activity of Bacillus spores. FEMS Immunol Med Microbiol. 2008 Jul;53(2):195-203. doi: 10.1111/j.1574-695X.2008.00415.x. Epub 2008 Apr 21.

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