Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)
| General Information of HIF (ID: HIFM0197) | |||||
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| HIF Name |
Regenerating islet-derived protein 3-beta
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| HIF Synonym(s) |
REG3B,REG3-beta
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| HIF Classification |
Antimicrobial peptide (AMP)
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| Molecular Function |
Antimicrobial
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| Description | REGIII human neutrophil peptide-2 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system. | [1] | |||
| Sequence | Click here to download the HIF sequence in FASTA format | ||||
| External Links | |||||
| Uniprot ID | |||||
| Microbe Species (MIC) Regulated by This HIF | |||||
|---|---|---|---|---|---|
| Bacillus subtilis (firmicutes) | MIC00136 | ||||
| Description | The recombinant purified RegIII had bactericidal activity against Bacillus subtilis and the effective doses for bactericidal activity were below 2.5 M. | [1] | |||
| Escherichia coli (enterobacteria) | MIC00516 | ||||
| Description | The recombinant purified RegIII had bactericidal activity against Escherichia coli and the effective doses for bactericidal activity were below 2.5 M. | [1] | |||
| Lactobacillus reuteri (firmicutes) | MIC00731 | ||||
| Description | Wild-type RegIII has the resistance of Lactobacillus reuteri despite its Lys-type peptidoglycan. | [1] | |||
| Salmonella enterica subsp. enterica (enterobacteria) | MIC01154 | ||||
| Description | Salmonella enterica subsp. enterica serovar Typhimurium induced mucosal lectin RegIII kills competing gut microbiota by reducing enzymatic activity. | [1] | |||
| Salmonella sp. (enterobacteria) | MIC01149 | ||||
| Description | Salmonella outer membrane lipopolysaccharides (LPS) could restrict access of RegIII beta to its target peptidoglycan in the periplasm. | [1] | |||
| Yersinia pseudotuberculosis (enterobacteria) | MIC01402 | ||||
| Description | The impaired clearance of Yersinia pseudotuberculosis in vivo may cause the approximately 2-fold decrease of Reg3b expression in Tlr2-deficient mice. | [1] | |||
| References | |||||
| 1 | Salmonella-induced mucosal lectin RegIII kills competing gut microbiota.PLoS One. 2011;6(6):e20749. doi: 10.1371/journal.pone.0020749. Epub 2011 Jun 9. | ||||
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