Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0111)
HIF Name
Liver-expressed antimicrobial peptide 1
HIF Synonym(s)
Hepcidin, LEAP-1, PLTR
HIF Classification
Antimicrobial peptide (AMP)
Molecular Function
Antibiotic; Antimicrobial; Fungicide; Hormone
Description Hepcidin has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system. [1]
Pfam Hepcidin (PF06446 )
Pathway TGF-beta signaling pathway (hsa04350 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
HEPC_HUMAN
APD ID
AP00193
Microbe Species (MIC) Regulated by This HIF
         Bacillus subtilis (firmicutes) MIC00136
             Description The IC50 values (Hepcidin concentration at which 50% of the bacterial growth is inhibited) for Pdp11, 51M6, Bacillus subtilis of 2.20, 14.61, 11.41 and 18.66M, respectively. [2]
         Escherichia coli (enterobacteria) MIC00516
             Description The IC50 value of Hepcidin for Escherichia coli is 18.66M. [2]
         Shewanella sp. (gamma-proteobacteria) MIC01177
             Description Hepcidin exerts in vitro antimicrobial enzymatic activity against bacterial strains isolated from Seabream skin (Pdp11 and 51M6, members of the Vibrionaceae family in the genus Shewanella). [2]
References
1 APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2 Impact of Tilapia hepcidin 2-3 dietary supplementation on the gut microbiota profile and immunomodulation in the grouper (Epinephelus lanceolatus).Sci Rep. 2019 Dec 13;9(1):19047. doi: 10.1038/s41598-019-55509-9.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.