| General Information of MIC (ID: MIC01326) |
| MIC Name |
Treponema socranskii (spirochaetes)
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| Body Site |
Oral Cavity
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| Lineage |
Kingdom: Bacteria
Phylum: Spirochaetes
Class: Spirochaetia
Order: Spirochaetales
Family: Spirochaetaceae
Genus: Treponema
Species: Treponema socranskii
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| Oxygen Sensitivity |
Facultative anaerobe
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| Microbial Metabolism |
Respiratory
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| Gram |
Negative
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| Genome Size (bp) |
2731774
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| Description |
Treponema socranskii is a facultatively anaerobic, Gram negative bacterium. It is one of the most frequently found oral spirochaetes in periodontitis and endodontic infections.
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| External Links |
Taxonomy ID |
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| GOLD Organism ID |
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| Disease Relevance |
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| Periodontal disease [ICD-11: DA0C] |
| Description |
Treponema socranskii was associated with the severity of periodontal tissue destruction. |
[1] |
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| Host Genetic Factors (HGFs) |
| rs73485008 |
| HGF ID |
HGF1640 |
HGF Info
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Class |
Single Nucleotide Polymorphism: Intron variant (SNP-IV) |
| Description |
The rs73485008 SNP was significantly associated with the abundance of Treponema socranskii (p-value<1.00E-08). |
[2] |
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| Host Immune Factors (HIFs) |
| Intercellular adhesion molecule 1 |
| HIF ID |
HIFM0123 |
HIF Info
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Class |
Cytokine (Cyt) |
| Description |
Treponema socranskii showed no enzymatic activity for intercellular adhesion molecule-1 (ICAM-1) in human monocyte cell line THP-1 cells. |
[3] |
| C-X-C motif chemokine 8 |
| HIF ID |
HIFM0153 |
HIF Info
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Class |
Cytokine (Cyt) |
| Description |
Treponema socranskii is associated with IL-8 expression. |
[3] |
| Tumor necrosis factor |
| HIF ID |
HIFM0226 |
HIF Info
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Class |
Cytokine (Cyt) |
| Description |
The abundance of Treponema socranskii is associated with TNF-Alpha. |
[3] |
| THP-1 monocyte cells |
| HIF ID |
HIFC0027 |
HIF Info
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Class |
Monocytes (Mono) |
| Description |
At the species level, Treponema socranskii is associated with THP-1 cells responses. |
[3] |
| Toll-like receptor 4 |
| HIF ID |
HIFM0219 |
HIF Info
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Class |
Toll-like receptor (TLR) |
| Description |
Treponema socranskii as a TLR4 antagonist. |
[3] |
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| Environmental Factor(s) |
| Disbiome ID |
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| gutMDisorder ID |
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| References |
| 1 |
Treponema socranskii, Treponema denticola, and Porphyromonas gingivalis are associated with severity of periodontal tissue destruction. J Periodontol. 2001 Oct;72(10):1354-63. doi: 10.1902/jop.2001.72.10.1354.
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| 2 |
Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
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| 3 |
Phenol/water extract of Treponema socranskii subsp. socranskii as an antagonist of Toll-like receptor 4 signalling. Microbiology. 2006 Feb;152(Pt 2):535-546. doi: 10.1099/mic.0.28470-0.
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