Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0123)
HIF Name
Intercellular adhesion molecule 1
HIF Synonym(s)
ICAM1, intercellular adhesion molecule 1, BB2, CD54, P3.58
HIF Classification
Cytokine (Cyt)
Molecular Function
Host cell receptor for virus entry; Receptor
Description ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. [1]
Pfam Intercellular adhesion molecule (ICAM), N-terminal domain (PF03921 )
Pathway AGE-RAGE signaling pathway in diabetic complications (hsa04933 )
African trypanosomiasis (hsa05143 )
Cell adhesion molecules (CAMs) (hsa04514 )
Epstein-Barr virus infection (hsa05169 )
Fluid shear stress and atherosclerosis (hsa05418 )
Human T-cell leukemia virus 1 infection (hsa05166 )
Influenza A (hsa05164 )
Kaposi sarcoma-associated herpesvirus infection (hsa05167 )
Leukocyte transendothelial migration (hsa04670 )
Malaria (hsa05144 )
NF-kappa B signaling pathway (hsa04064 )
Natural killer cell mediated cytotoxicity (hsa04650 )
Rheumatoid arthritis (hsa05323 )
Staphylococcus aureus infection (hsa05150 )
TNF signaling pathway (hsa04668 )
Viral myocarditis (hsa05416 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
ICAM1_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Treponema socranskii (spirochaetes) MIC01326
             Description Treponema socranskii showed no enzymatic activity for intercellular adhesion molecule-1 (ICAM-1) in human monocyte cell line THP-1 cells. [2]
References
1 Pharmacological blockage of ICAM-1 improves angiotensin II-induced cardiac remodeling by inhibiting adhesion of LFA-1(+) monocytes.Am J Physiol Heart Circ Physiol. 2019 Dec 1;317(6):H1301-H1311. doi: 10.1152/ajpheart.00566.2019. Epub 2019 Nov 15.
2 Phenol/water extract of Treponema socranskii subsp. socranskii as an antagonist of Toll-like receptor 4 signalling. Microbiology. 2006 Feb;152(Pt 2):535-546. doi: 10.1099/mic.0.28470-0.

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