General Information of HIF (ID: HIFC0027)
HIF Name	THP-1 monocyte cells
HIF Synonym(s)	THP-1, THP-1 cells
HIF Classification	Monocytes (Mono)
Description	THP-1 is a human leukemia monocytic cell line, which has been extensively used to study monocyte/macrophage functions, mechanisms, signaling pathways, and nutrient and drug transport. This cell line has become a common model to estimate modulation of monocyte and macrophage activities.				[1]

Microbe Species (MIC) Regulated by This HIF
Brucella suis (alpha-proteobacteria)			MIC00275
Description	THP-1 cells produced significant amounts of inflammatory cytokines such as IL-1, IL-6, and IL-8 during Brucella suis infection.				[2]
Clostridioides difficile (firmicutes)			MIC00396
Description	Clostridium difficile Toxins A and B induced inflammasome activation and signaling in THP-1 cells.				[3]
Rothia dentocariosa (actinobacteria)			MIC01124
Description	Exposure of THP-1 cells to Rothia dentocariosa induced the production of TNF-alpha.				[4]
Streptococcus intermedius (firmicutes)			MIC01255
Description	Streptococcus intermedius can cause cytokine inductions in THP1 cells responses.				[5]
Treponema lecithinolyticum (spirochaetes)			MIC01323
Description	The major surface proteins of Treponema lecithinolyticum upregulated intercellular adhesion molecule 1 and proinflammatory cytokines in human monocytic THP-1 cells.				[6]
Treponema maltophilum (spirochaetes)			MIC01324
Description	The major surface proteins of Treponema maltophilum upregulated intercellular adhesion molecule 1 and proinflammatory cytokines in human monocytic THP-1 cells.				[6]
Treponema socranskii (spirochaetes)			MIC01326
Description	At the species level, Treponema socranskii is associated with THP-1 cells responses.				[7]

References
1	THP-1 Cells and Pro-inflammatory Cytokine Production: An in Vitro Tool for Functional Characterization of NOD1/NOD2 Antagonists.Int J Mol Sci. 2019 Aug 30;20(17):4265. doi: 10.3390/ijms20174265.
2	The innate immune response against Brucella in humans. Vet Microbiol. 2002 Dec 20;90(1-4):383-94. doi: 10.1016/s0378-1135(02)00223-7.
3	Immune responses to Clostridium difficile infection.Trends Mol Med. 2012 Nov;18(11):658-66. doi: 10.1016/j.molmed.2012.09.005. Epub 2012 Oct 16.
4	Rothia dentocariosa induces TNF-alpha production in a TLR2-dependent manner. Pathog Dis. 2014 Jun;71(1):65-8. doi: 10.1111/2049-632X.12115. Epub 2013 Dec 16.
5	Histone-like DNA binding protein of Streptococcus intermedius induces the expression of pro-inflammatory cytokines in human monocytes via activation of ERK1/2 and JNK pathways. Cell Microbiol. 2008 Jan;10(1):262-76. doi: 10.1111/j.1462-5822.2007.01040.x. Epub 2007 Sep 20.
6	Upregulation of intercellular adhesion molecule 1 and proinflammatory cytokines by the major surface proteins of Treponema maltophilum and Treponema lecithinolyticum, the phylogenetic group IV oral spirochetes associated with periodontitis and endodontic infections. Infect Immun. 2005 Jan;73(1):268-76. doi: 10.1128/IAI.73.1.268-276.2005.
7	Phenol/water extract of Treponema socranskii subsp. socranskii as an antagonist of Toll-like receptor 4 signalling. Microbiology. 2006 Feb;152(Pt 2):535-546. doi: 10.1099/mic.0.28470-0.

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