General Information of MIC (ID: MIC00275)
MIC Name	Brucella suis (alpha-proteobacteria)
Body Site	Blood
Lineage	Kingdom: Bacteria Phylum: Proteobacteria Class: Alphaproteobacteria Order: Rhizobiales Family: Brucellaceae Genus: Brucella Species: Brucella suis
Oxygen Sensitivity	Facultative anaerobe
Microbial Metabolism	Respiratory
Gram	Negative
Genome Size (bp)	3313865
No. of Coding Genes	3077
No. of Non-Coding Genes	64
No. of Small Non-Coding Genes	64
No. of Gene Transcripts	3141
No. of Base Pairs	3313865
Description	Brucella suis is a Gram-negative bacterium. It causes swine brucellosis, a zoonosis that affects pigs. The disease typically causes chronic inflammatory lesions in the reproductive organs of susceptible animals or orchitis, and may even affect joints and other organs.
External Links	Taxonomy ID	29461
	Genome Assembly ID	ASM74043v1
	GOLD Organism ID	Go0545995

Host Immune Factors (HIFs)
Interferon-6
HIF ID	HIFM0151	HIF Info	Class	Cytokine (Cyt)
Description	Brucella suis-infected macrophages produced IL-6.				[1]
Tumor necrosis factor
HIF ID	HIFM0226	HIF Info	Class	Cytokine (Cyt)
Description	This impairment of Brucella suis multiplication is due to both soluble factors released from activated gammadeltaT-cells (including TNF-alpha and IFN-gamma) and to a contact-dependent cytotoxicity directed against the infected cells.				[1]
Interferon gamma
HIF ID	HIFM0260	HIF Info	Class	Cytokine (Cyt)
Description	This impairment of Brucella suis multiplication is due to both soluble factors released from activated gammadeltaT-cells (including TNF-alpha and IFN-gamma) and to a contact-dependent cytotoxicity directed against the infected cells.				[1]
Interleukin-1
HIF ID	HIFM0263	HIF Info	Class	Cytokine (Cyt)
Description	Brucella suis-infected macrophages which could produce IL-1.				[1]
THP-1 monocyte cells
HIF ID	HIFC0027	HIF Info	Class	Monocytes (Mono)
Description	THP-1 cells produced significant amounts of inflammatory cytokines such as IL-1, IL-6, and IL-8 during Brucella suis infection.				[1]
Vg9Vd2 T cells
HIF ID	HIFC0089	HIF Info	Class	T cells (TCs)
Description	Brucella suis stimulated human Vg9Vd2 T-cells to secrete TNF alpha, IFN-gamma and other not yet identified cytokines.				[1]

Environmental Factor(s)
Disbiome ID			1441

References
1	The innate immune response against Brucella in humans. Vet Microbiol. 2002 Dec 20;90(1-4):383-94. doi: 10.1016/s0378-1135(02)00223-7.

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