Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01124)
MIC Name Rothia dentocariosa (actinobacteria)
MIC Synonyms Actinomyces dentocariosus
Body Site Mucosa
Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Micrococcales
Family: Micrococcaceae
Genus: Rothia
Species: Rothia dentocariosa
Oxygen Sensitivity Aerobe or Anaerobe
Microbial Metabolism Respiratory
Gram Positive
Host Relationship Commensal
Genome Size (bp) 2506025
No. of Coding Genes 2025
No. of Non-Coding Genes 53
No. of Small Non-Coding Genes 53
No. of Gene Transcripts 2078
No. of Base Pairs 2639435
Description Rothia dentocariosa is a species of Gram positive that grows under aerobic or anaerobic conditions and is a normal commensal of the oral cavity bacteria. It usually associated with dental caries and periodontal disease and has a variety of presentations, including septic arthritis, pneumonia, septicemias in renal transplant patients, and arteriovenous infections.
External Links Taxonomy ID
2047
Genome Assembly ID
ASM76376v1
GOLD Organism ID
Go0004504
Disease Relevance
          Dental caries  [ICD-11: DA08]
             Description Salivary counts of Rothia dentocariosa may be useful for screening/assessing children's risk of developing caries. [1]
          Periodontal disease  [ICD-11: DA0C]
             Description Rothia dentocariosa was associated with periodontal disease. [2]
          Pneumonia  [ICD-11: CA40]
             Description Rothia dentocariosa was associated with pneumonia. [2]
          Septic arthritis  [ICD-11: FA10]
             Description Rothia dentocariosa was associated with septic arthritis. [2]
Host Genetic Factors (HGFs)
          rs10148701
             HGF ID HGF1750 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs10148701 SNP was significantly associated with the abundance of Rothia dentocariosa (p-value<1.00E-08). [3]
Host Immune Factors (HIFs)
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Rothia dentocariosa could induce TNF-alpha production in a TLR2-dependent manner. [4]
          THP-1 monocyte cells
             HIF ID HIFC0027 HIF Info       Class Monocytes (Mono)
             Description Exposure of THP-1 cells to Rothia dentocariosa induced the production of TNF-alpha. [4]
          Nuclear factor kappa B signaling pathway
             HIF ID HIFP0028 HIF Info       Class Signaling pathway (SP)
             Description The Rothia dentocariosa-infected cells could induce NF-kappaB activation in the transfected HEK293 cells in a dose-dependent manner. [4]
          Toll-like receptor 2
             HIF ID HIFM0217 HIF Info       Class Toll-like receptor (TLR)
             Description Rothia dentocariosa induced TNF-alpha production in a TLR2-dependent manner. [4]
Environmental Factor(s)
             Disbiome ID
      1130
             gutMDisorder ID
      gm0577
References
1 Salivary Microbiome Diversity in Caries-Free and Caries-Affected Children. Int J Mol Sci. 2016 Nov 25;17(12):1978. doi: 10.3390/ijms17121978.
2 Rothia dentocariosa Endocarditis: An Especially Rare Case in a Previously Healthy Man. Tex Heart Inst J. 2016 Jun 1;43(3):255-7. doi: 10.14503/THIJ-15-5068. eCollection 2016 Jun.
3 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
4 Rothia dentocariosa induces TNF-alpha production in a TLR2-dependent manner. Pathog Dis. 2014 Jun;71(1):65-8. doi: 10.1111/2049-632X.12115. Epub 2013 Dec 16.

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