Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01323)
MIC Name Treponema lecithinolyticum (spirochaetes)
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Spirochaetes
Class: Spirochaetia
Order: Spirochaetales
Family: Spirochaetaceae
Genus: Treponema
Species: Treponema lecithinolyticum
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 2338485
Description Treponema lecithinolyticum is a facultatively anaerobic, Gram negative bacterium. A molecular epidemiological study showed that this novel species is present at high frequency in the subgingival plaque samples of rapidly progressive periodontitis patients.
External Links Taxonomy ID
53418
Genome Assembly ID
ASM46805v1
GOLD Organism ID
Go0178537
Disease Relevance
          Periodontal disease  [ICD-11: DA0C]
             Description Treponema lecithinolyticum can be involved in the pathogenesis of periradicular diseases. [1]
Host Immune Factors (HIFs)
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Treponema lecithinolyticum activated human monocytes and PDL cells to induce production of proinflammatory cytokines, such as IL-1bata. [2]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Treponema lecithinolyticum activated human monocytes and PDL cells to induce production of proinflammatory cytokines, such as IL-6. [2]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description Treponema lecithinolyticum activated human monocytes and PDL cells to induce production of proinflammatory cytokines, such as IL-8. [2]
          THP-1 monocyte cells
             HIF ID HIFC0027 HIF Info       Class Monocytes (Mono)
             Description The major surface proteins of Treponema lecithinolyticum upregulated intercellular adhesion molecule 1 and proinflammatory cytokines in human monocytic THP-1 cells. [2]
          Nuclear factor kappa B signaling pathway
             HIF ID HIFP0028 HIF Info       Class Signaling pathway (SP)
             Description The abundance of Treponema lecithinolyticum is associated with NF-B activation. [2]
Environmental Factor(s)
             Disbiome ID
      715
             gutMDisorder ID
      gm0651
References
1 PCR-based identification of Treponema maltophilum, T amylovorum, T medium, and T lecithinolyticum in primary root canal infections. Arch Oral Biol. 2003 Jul;48(7):495-502. doi: 10.1016/s0003-9969(03)00092-x.
2 Upregulation of intercellular adhesion molecule 1 and proinflammatory cytokines by the major surface proteins of Treponema maltophilum and Treponema lecithinolyticum, the phylogenetic group IV oral spirochetes associated with periodontitis and endodontic infections. Infect Immun. 2005 Jan;73(1):268-76. doi: 10.1128/IAI.73.1.268-276.2005.

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