Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01324)
MIC Name Treponema maltophilum (spirochaetes)
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Spirochaetes
Class: Spirochaetia
Order: Spirochaetales
Family: Spirochaetaceae
Genus: Treponema
Species: Treponema maltophilum
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 2527074
Description Treponema maltophillum is a facultative anaerobic, Gram negative bacterium of treponema. It is implicated as a pathogen in chronic periodontitis which can induce bone loss.
External Links Taxonomy ID
51160
Genome Assembly ID
Trep_malt_ATCC_51939_V1
GOLD Organism ID
Go0202238
Disease Relevance
          Periodontal disease  [ICD-11: DA0C]
             Description Treponema maltophilum can be involved in the pathogenesis of periradicular diseases. [1]
Host Genetic Factors (HGFs)
          rs7337165
             HGF ID HGF2213 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs7337165 SNP was significantly associated with the abundance of Treponema maltophilum (p-value<1.00E-08). [2]
Host Immune Factors (HIFs)
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Treponema maltophilum is associated with IL-1beta. [3]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Treponema maltophilum activated human monocytes and PDL cells to induce production of proinflammatory cytokines, such as IL-6. [3]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description Treponema maltophilum activated human monocytes and PDL cells to induce production of proinflammatory cytokines, such as IL-8. [3]
          THP-1 monocyte cells
             HIF ID HIFC0027 HIF Info       Class Monocytes (Mono)
             Description The major surface proteins of Treponema maltophilum upregulated intercellular adhesion molecule 1 and proinflammatory cytokines in human monocytic THP-1 cells. [3]
          Nuclear factor kappa B signaling pathway
             HIF ID HIFP0028 HIF Info       Class Signaling pathway (SP)
             Description The abundance of Treponema maltophilum is associated with NF-B activation. [3]
Environmental Factor(s)
             Disbiome ID
      621
             gutMDisorder ID
      gm0651
References
1 PCR-based identification of Treponema maltophilum, T amylovorum, T medium, and T lecithinolyticum in primary root canal infections. Arch Oral Biol. 2003 Jul;48(7):495-502. doi: 10.1016/s0003-9969(03)00092-x.
2 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
3 Upregulation of intercellular adhesion molecule 1 and proinflammatory cytokines by the major surface proteins of Treponema maltophilum and Treponema lecithinolyticum, the phylogenetic group IV oral spirochetes associated with periodontitis and endodontic infections. Infect Immun. 2005 Jan;73(1):268-76. doi: 10.1128/IAI.73.1.268-276.2005.

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