Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01255)
MIC Name Streptococcus intermedius (firmicutes)
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus intermedius
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Host Relationship Commensal
Genome Size (bp) 1908201
Description Streptococcus intermedius is an aerotolerant anaerobic commensal bacterium and a member of the Streptococcus anginosus group. Despite being commensal organisms, members of the S. anginosus group display wide pathogenic potential. S. intermedius has been isolated from patients with periodontitis and fatal purulent infections, especially brain and liver abscesses.
External Links Taxonomy ID
1338
Genome Assembly ID
ASM46335v1
GOLD Organism ID
Go0005217
Host Immune Factors (HIFs)
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Streptococcus intermedius could induce IL-1beta expression. [1]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description Streptococcus intermedius could induce the IL-8 expression. [1]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Streptococcus intermedius could stimulate and induce the production of proinflammatory cytokines (TNF-Alpha). [1]
          THP-1 monocyte cells
             HIF ID HIFC0027 HIF Info       Class Monocytes (Mono)
             Description Streptococcus intermedius can cause cytokine inductions in THP1 cells responses. [1]
          Extracellular signal-regulated kinase 1 signaling pathway
             HIF ID HIFP0008 HIF Info       Class Signaling pathway (SP)
             Description Histonelike DNA binding protein of Streptococcus intermedius could induces the expression of proinflammatory cytokines in human monocytes via activation of ERK1/2 and JNK pathways [1]
          Extracellular signal-regulated kinase 2 signaling pathway
             HIF ID HIFP0009 HIF Info       Class Signaling pathway (SP)
             Description Histonelike DNA binding protein of Streptococcus intermedius could induces the expression of proinflammatory cytokines in human monocytes via activation of ERK1/2 and JNK pathways [1]
          Jun N-terminal kinase signaling pathway
             HIF ID HIFP0021 HIF Info       Class Signaling pathway (SP)
             Description Histonelike DNA binding protein of Streptococcus intermedius could induces the expression of proinflammatory cytokines in human monocytes via activation of ERK1/2 and JNK pathways [1]
          Toll-like receptor 2
             HIF ID HIFM0217 HIF Info       Class Toll-like receptor (TLR)
             Description Streptococcus intermedius is associated with Toll-like receptor 2 activation. [1]
Environmental Factor(s)
             Disbiome ID
      31
             gutMDisorder ID
      gm0624
References
1 Histone-like DNA binding protein of Streptococcus intermedius induces the expression of pro-inflammatory cytokines in human monocytes via activation of ERK1/2 and JNK pathways. Cell Microbiol. 2008 Jan;10(1):262-76. doi: 10.1111/j.1462-5822.2007.01040.x. Epub 2007 Sep 20.

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