Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFP0008)
HIF Name	Extracellular signal-regulated kinase 1 signaling pathway
HIF Synonym(s)	ERK1 signal pathways, ERK1 signaling pathway
HIF Classification	Signaling pathway (SP)
Description	ERK1 signaling play a critical role in cell proliferation by regulating cell growth and cell cycle progression	[1]

Microbe Species (MIC) Regulated by This HIF
Saccharomyces cerevisiae (budding yeasts)		MIC01145
Description	Saccharomyces cerevisiae could inhibite ETEC-Mediated ERK1 Signaling Pathways.		[2]
Streptococcus intermedius (firmicutes)		MIC01255
Description	Histonelike DNA binding protein of Streptococcus intermedius could induces the expression of proinflammatory cytokines in human monocytes via activation of ERK1/2 and JNK pathways		[3]

References
1	The ERK Cascade: Distinct Functions within Various Subcellular Organelles.Genes Cancer. 2011 Mar;2(3):195-209. doi: 10.1177/1947601911407328.
2	Saccharomyces cerevisiae modulates immune gene expressions and inhibits ETEC-mediated ERK1/2 and p38 signaling pathways in intestinal epithelial cells. PLoS One. 2011 Apr 4;6(4):e18573. doi: 10.1371/journal.pone.0018573.
3	Histone-like DNA binding protein of Streptococcus intermedius induces the expression of pro-inflammatory cytokines in human monocytes via activation of ERK1/2 and JNK pathways. Cell Microbiol. 2008 Jan;10(1):262-76. doi: 10.1111/j.1462-5822.2007.01040.x. Epub 2007 Sep 20.

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