Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFP0021)
HIF Name
Jun N-terminal kinase signaling pathway
HIF Synonym(s)
Jnk, JNK signaling pathway
HIF Classification
Signaling pathway (SP)
Description JNK signaling pathway is such a death pathway that control cell death. There are two main downstream signaling of JNK pathway: one is activation of death signaling such c-Jun, Fos and apoptosis signaling such as BIM, BAD, BAX protein or active P53 transcription, to promote cell apoptosis; [1]
Microbe Species (MIC) Regulated by This HIF
         Streptococcus intermedius (firmicutes) MIC01255
             Description Histonelike DNA binding protein of Streptococcus intermedius could induces the expression of proinflammatory cytokines in human monocytes via activation of ERK1/2 and JNK pathways [2]
References
1 JNK pathway signaling: a novel and smarter therapeutic targets for various biological diseases.Future Med Chem. 2015;7(15):2065-86. doi: 10.4155/fmc.15.132. Epub 2015 Oct 27.
2 Histone-like DNA binding protein of Streptococcus intermedius induces the expression of pro-inflammatory cytokines in human monocytes via activation of ERK1/2 and JNK pathways. Cell Microbiol. 2008 Jan;10(1):262-76. doi: 10.1111/j.1462-5822.2007.01040.x. Epub 2007 Sep 20.

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