General Information of MIC (ID: MIC00964)
MIC Name	Parvimonas micra (firmicutes)
MIC Synonyms	Streptococcus anaerobius micros
Body Site	Oral Cavity
Lineage	Kingdom: Bacteria Phylum: Firmicutes Class: Tissierellia Order: Tissierellales Family: Peptoniphilaceae Genus: Parvimonas Species: Parvimonas micra
Oxygen Sensitivity	Obligate anaerobe
Microbial Metabolism	Asaccharolytic; Proteolytic; Fermentative
Gram	Positive
Host Relationship	Pathogen; Commensal
Genome Size (bp)	1627009
No. of Coding Genes	1419
No. of Non-Coding Genes	57
No. of Small Non-Coding Genes	57
No. of Gene Transcripts	1476
No. of Base Pairs	1627009
Description	Parvimonas micra is an obligately anaerobic, Gram positive bacterium. The bacterium has been deemed a commensal pathogen in the human oral cavity, where it is most abundant in the subgingival dental plaque. It is regarded as one of the pathogens that causes periodontitis in humans.
External Links	Taxonomy ID	33033
	Genome Assembly ID	ASM80029v1
	GOLD Organism ID	Go0000916
Disease Relevance
Colorectal cancer  [ICD-11: 2B91]
Description	Parvimonas micra was associated with genetic variants in Colorectal cancer.				[1]
Gastric cancer  [ICD-11: 2B72]
Description	Parvimonas micra had a porential role in Gastric cancer progression.				[2]
Periodontal disease  [ICD-11: DA0C]
Description	Subjects with Refractory periodontitis had high frequency of Micromonas micros.				[3]

Host Genetic Factors (HGFs)
CD44
HGF ID	HGF2333	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	Parvimonas micra had a significant difference in the percentage abundance between the EAE-induced CD44 wide type and the CD44 knock out mice (p-value<0.05).				[4]

Host Immune Factors (HIFs)
Nucleotide binding oligomerization domain containing 2 signaling pathway
HIF ID	HIFP0029	HIF Info	Class	Signaling pathway (SP)
Description	Parvimonas micra has the highest NOD2 stimulatory activity.				[5]

Environmental Factor(s)
Disbiome ID			353
gutMDisorder ID			gm0504

References
1	M-GWAS for the gut microbiome in Chinese adults illuminates on complex diseases. bioRxiv, 2019.
2	Mucosal microbiome dysbiosis in gastric carcinogenesis. Gut. 2018 Jun;67(6):1024-1032. doi: 10.1136/gutjnl-2017-314281. Epub 2017 Aug 1.
3	Comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray. J Periodontol. 2009 Sep;80(9):1421-32. doi: 10.1902/jop.2009.090185.
4	CD44 deletion leading to attenuation of experimental autoimmune encephalomyelitis results from alterations in gut microbiome in mice.Eur J Immunol. 2017 Jul;47(7):1188-1199. doi: 10.1002/eji.201646792. Epub 2017 Jun 6.
5	TLR4, NOD1 and NOD2 mediate immune recognition of putative newly identified periodontal pathogens. Mol Oral Microbiol. 2016 Jun;31(3):243-258. doi: 10.1111/omi.12116. Epub 2015 Sep 10.

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