Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0046)
HIF Name
T-cell-specific surface glycoprotein CD28
HIF Synonym(s)
CD28 molecule, Tp44
HIF Classification
T-cell receptor (TCR)
Description T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. [1]
Pfam ICOS V-set domain (PF15910 )
Pathway Allograft rejection (hsa05330 )
Autoimmune thyroid disease (hsa05320 )
Cell adhesion molecules (CAMs) (hsa04514 )
Graft-versus-host disease (hsa05332 )
Intestinal immune network for IgA production (hsa04672 )
Measles (hsa05162 )
PD-L1 expression and PD-1 checkpoint pathway in cancer (hsa05235 )
Rheumatoid arthritis (hsa05323 )
Systemic lupus erythematosus (hsa05322 )
T cell receptor signaling pathway (hsa04660 )
Type I diabetes mellitus (hsa04940 )
Viral myocarditis (hsa05416 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CD28_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Coxiella burnetii (gamma-proteobacteria) MIC00467
             Description Increasing injected doses to 5 106 Coxiella burnetii organisms did not change mortality and morbidity of wt and CD28 / mice. [2]
         Listeria monocytogenes (firmicutes) MIC00771
             Description The lack of CD28 is associated with elevated bacterial loads at initial times post Listeria monocytogenes infection. [2]
         Pneumocystis carinii (ascomycetes) MIC01791
             Description Lacking CD28 display increased IFN- expression during Pneumocystis carinii infection. [2]
         Streptococcus pyogenes (firmicutes) MIC01267
             Description A peptide antagonist of CD28 signaling attenuates toxic shock and necrotizing soft-tissue infection induced by Streptococcus pyogenes. [3]
References
1 T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.Science. 2017 Mar 31;355(6332):1428-1433. doi: 10.1126/science.aaf1292. Epub 2017 Mar 9.
2 Role for the CD28 molecule in the control of Coxiella burnetii infection.Infect Immun. 2006 Mar;74(3):1800-8. doi: 10.1128/IAI.74.3.1800-1808.2006.
3 A peptide antagonist of CD28 signaling attenuates toxic shock and necrotizing soft-tissue infection induced by Streptococcus pyogenes.J Infect Dis. 2013 Jun 15;207(12):1869-77. doi: 10.1093/infdis/jit104. Epub 2013 Mar 14.

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