Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0140)
HIF Name
Interleukin-1 receptor antagonist protein
HIF Synonym(s)
Interleukin-1 receptor antagonist protein, Il1rn, IRAP, IL-1ra, IL-1RN
HIF Classification
Cytokine (Cyt)
Description Interleukin-1 receptor antagonist [1]
Pfam Interleukin-1 / 18 (PF00340 )
Pathway Cytokine-cytokine receptor interaction (hsa04060 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
IL1RA_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Coxiella burnetii (gamma-proteobacteria) MIC00467
             Description Coxiella burnetii replication is associated with an M2 program characterized by the up-regulation of IL-1 receptor antagonist (IL1-ra) in monocytes. [2]
References
1 A Brief History of IL-1 and IL-1 Ra in Rheumatology.Front Pharmacol. 2017 May 23;8:293. doi: 10.3389/fphar.2017.00293. eCollection 2017.
2 Immune response and Coxiella burnetii invasion. Adv Exp Med Biol. 2012;984:287-98. doi: 10.1007/978-94-007-4315-1_15.

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