General Information of MIC (ID: MIC01028)
MIC Name	Prevotellaceae (CFB bacteria)
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Bacteroidetes Class: Bacteroidia Order: Bacteroidales Family: Prevotellaceae
Oxygen Sensitivity	Anaerobe
Microbial Metabolism	Saccharolytic; Fermentative
Gram	Negative
Description	The family Prevotellaceae is composed of four genera. The genus Prevotella is known for its role in the human gastrointestinal microbiota. As a human pathogen known for creating periodontal and tooth problems, Prevotella has long been studied to counteract its pathogenesis.
External Links	Taxonomy ID	171552
Disease Relevance
Parkinsonism  [ICD-11: 8A00]
Description	Prevotellaceae were reduced in fecal samples from patients with Parkinsons disease compared to matched controls.				[1]
Ulcerative colitis  [ICD-11: DD71]
Description	The differences at the phylum level between the Ulcerative colitis and Familial adenomatous polyposis cohorts corresponded to significant increases in the levels of the proteobacterial families Comamonadaceae, Moraxellaceae and Alcaligenaceae in tandem with a significant reduction in the Bacteroidetes families Bacteroidaceae and Prevotellaceae and the Firmicutes family Ruminococcaceae in Ulcerative colitis.				[2]

Host Genetic Factors (HGFs)
NINJ1
HGF ID	HGF2340	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of NINJ1 increased the relative abundance of Prevotellaceae.				[3]
rs2072493
HGF ID	HGF1277	HGF Info	Class	Single Nucleotide Polymorphism: Missense variant (SNP-MV)
Description	The variant gene TLR5 of innate immunity rs2072493 is significantly associated with the abundance of gut micriobiota Prevotellaceae (p-value=0.0001).				[4]

Host Immune Factors (HIFs)
Transforming growth factor beta-2 proprotein
HIF ID	HIFM0213	HIF Info	Class	Cytokine (Cyt)
Description	The increased abundance of the Prevotellaceae was associated with the enriched concentrations of TGF- in serum.				[5]
Immunoglobulin A
HIF ID	HIFM0272	HIF Info	Class	Immunoglobulin (Ig)
Description	Prevotellaceae family is associated with antibiotic biosynthesis and transport of secondary metabolites.				[5]

Environmental Factor(s)
Disbiome ID			235
gutMDisorder ID			gm0540

References
1	Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls. Parkinsonism Relat Disord. 2016 Nov;32:66-72. doi: 10.1016/j.parkreldis.2016.08.019. Epub 2016 Aug 26.
2	The bacteriology of pouchitis: a molecular phylogenetic analysis using 16S rRNA gene cloning and sequencing. Ann Surg. 2010 Jul;252(1):90-8. doi: 10.1097/SLA.0b013e3181e3dc8b.
3	Ninjurin1 deficiency aggravates colitis development by promoting M1 macrophage polarization and inducing microbial imbalance.FASEB J. 2020 Jun;34(6):8702-8720. doi: 10.1096/fj.201902753R. Epub 2020 May 8.
4	Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
5	Prebiotic, immuno-stimulating and gut microbiota-modulating effects of Lycium barbarum polysaccharide. Biomed Pharmacother. 2020 Jan;121:109591. doi: 10.1016/j.biopha.2019.109591. Epub 2019 Nov 13.

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