Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00788)
MIC Name Megasphaera elsdenii (firmicutes)
MIC Synonyms Peptostreptococcus elsdenii
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Negativicutes
Order: Veillonellales
Family: Veillonellaceae
Genus: Megasphaera
Species: Megasphaera elsdenii
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative; Utilize hydrogen as energy source
Gram Negative
Host Relationship Commensal
Genome Size (bp) 2412274
No. of Coding Genes 2017
No. of Non-Coding Genes 92
No. of Small Non-Coding Genes 92
No. of Gene Transcripts 2109
No. of Base Pairs 2412274
Description Megasphaera elsdenii is a Gram-negative, obligately anaerobic, saccharolytic, fermentative, lactate fermented to propionate, commensal ruminal bacterium.
External Links Taxonomy ID
907
Genome Assembly ID
ASM76319v1
GOLD Organism ID
Go0519010
Host Genetic Factors (HGFs)
          SLC15A1
             HGF ID HGF2354 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of PepT1 could decrease the abundance of Magasphaera. [1]
          rs7150255
             HGF ID HGF2209 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs7150255 SNP was significantly associated with the abundance of Megasphaera (p-value=4.03E-06). [2]
          rs4879677
             HGF ID HGF1604 HGF Info       Class Single Nucleotide Polymorphism: Upstream variant (SNP-UV)
             Description The rs4879677 SNP was significantly associated with the abundance of Megasphaera (p-value=3.86E-06). [2]
          rs2150022
             HGF ID HGF1964 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs2150022 SNP was significantly associated with the abundance of Megasphaera (p-value=3.86E-06). [2]
          rs2069845
             HGF ID HGF1721 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The variant gene IL-6 of innate immunity rs2069845 is significantly associated with the abundance of gut micriobiota Megasphaera (p-value=0.0304). [3]
          rs10968061
             HGF ID HGF1963 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs10968061 SNP was significantly associated with the abundance of Megasphaera (p-value=3.86E-06). [2]
          rs7782745
             HGF ID HGF2007 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs7782745 SNP was significantly associated with the relative abundance of Megasphaera (p-value=9.90E-10). [4]
          rs73005672
             HGF ID HGF1856 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs73005672 SNP was significantly associated with the relative abundance of Megasphaera (p-value=1.82E-08). [4]
          rs6683259
             HGF ID HGF1833 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6683259 SNP was significantly associated with the relative abundance of Megasphaera (p-value=5.28E-09). [4]
          rs17806643
             HGF ID HGF2245 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs17806643 SNP was significantly associated with the relative abundance of Megasphaera (p-value=5.97E-09). [4]
          rs11608507
             HGF ID HGF2222 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs11608507 SNP was significantly associated with the relative abundance of Megasphaera (p-value=3.25E-08). [4]
          rs10112815
             HGF ID HGF1980 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs10112815 SNP was significantly associated with the relative abundance of Megasphaera (p-value=2.86E-08). [4]
Host Immune Factors (HIFs)
          Transforming growth factor beta-2 proprotein
             HIF ID HIFM0213 HIF Info       Class Cytokine (Cyt)
             Description Megasphaera elsdenii extend the lifespan of Caenorhabditis elegans via the transforming growth factor-beta (TGF-) pathway associated with anti-inflammatory processes in the innate immune system. [5]
          Dendritic cells
             HIF ID HIFC0003 HIF Info       Class Dendritic cells (DCs)
             Description Megasphaera elsdenii can induce dendritic cells maturation. [6]
          CD16+ Natural Killer cells
             HIF ID HIFC0094 HIF Info       Class Natural killer cells (NKCs)
             Description The increased proportion of CD16+ NK cells was associated with the decrease of gut commensal bacteria(Megasphaera). [7]
          T helper type 2 cells
             HIF ID HIFC0085 HIF Info       Class T cells (TCs)
             Description Prevotella timonensis could inhibite the enzyme activity to suppress T-helper type 2 cells responses. [6]
          T-cell surface glycoprotein CD4
             HIF ID HIFM0050 HIF Info       Class T-cell receptor (TCR)
             Description HIV-pneumonia patients with low CD4 counts exhibited enrichment of specific Megasphaera(false discovery rate q < 0.05, read difference 100 reads, and presence in 50%). [8]
Environmental Factor(s)
             Disbiome ID
      398
             gutMDisorder ID
      gm0435
References
1 Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations.NPJ Biofilms Microbiomes. 2020 Jul 21;6(1):27. doi: 10.1038/s41522-020-0137-y.
2 Genome-Wide Association Studies of the Human Gut Microbiota.PLoS One. 2015 Nov 3;10(11):e0140301. doi: 10.1371/journal.pone.0140301. eCollection 2015.
3 Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
4 Association of host genome with intestinal microbial composition in a large healthy cohort.Nat Genet. 2016 Nov;48(11):1413-1417. doi: 10.1038/ng.3693. Epub 2016 Oct 3.
5 Lifespan Extension of Caenorhabditis elegans by Butyricicoccus pullicaecorum and Megasphaera elsdenii with Probiotic Potential. Curr Microbiol. 2018 May;75(5):557-564. doi: 10.1007/s00284-017-1416-6. Epub 2017 Dec 8.
6 Vaginal dysbiosis associated-bacteria Megasphaera elsdenii and Prevotella timonensis induce immune activation via dendritic cells. J Reprod Immunol. 2020 Apr;138:103085. doi: 10.1016/j.jri.2020.103085. Epub 2020 Jan 22.
7 Dysbiosis of gut microbiome affecting small intestine morphology and immune balance: a rhesus macaque model.Zool Res. 2020 Jan 18;41(1):20-31. doi: 10.24272/j.issn.2095-8137.2020.004.
8 Gut microbiota in HIV-pneumonia patients is related to peripheral CD4 counts, lung microbiota, and in vitro macrophage dysfunction. Microbiome. 2019 Mar 11;7(1):37. doi: 10.1186/s40168-019-0651-4.

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