Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01007)
MIC Name Prevotella bivia (CFB bacteria)
MIC Synonyms Bacteroides bivius
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Prevotellaceae
Genus: Prevotella
Species: Prevotella bivia
Oxygen Sensitivity Anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Negative
Host Relationship Commensal
Genome Size (bp) 2576472
No. of Coding Genes 2454
No. of Non-Coding Genes 50
No. of Small Non-Coding Genes 50
No. of Gene Transcripts 2504
No. of Base Pairs 2576472
Description Prevotella bivia was previously known as Bacteroides bivius. It is a Gram-negative, anaerobic bacterium that inhabits the female genital. The bacterium has been associated with endometritis, an inflammation of the inner lining of the uterus.
External Links Taxonomy ID
28125
Genome Assembly ID
ASM157440v1
GOLD Organism ID
Go0004645
Disease Relevance
          Vaginitis  [ICD-11: GA02]
             Description Prevotella bivia was associated with bacterial vaginosis. [1]
Host Immune Factors (HIFs)
          C-C motif chemokine 20
             HIF ID HIFM0023 HIF Info       Class Cytokine (Cyt)
             Description Prevotella bivia could induce higher level expression of CCL20. [2]
          C-C motif chemokine 5
             HIF ID HIFM0033 HIF Info       Class Cytokine (Cyt)
             Description Prevotella bivia could induce higher levels of CCL5 expression. [2]
          C-X-C motif chemokine 2
             HIF ID HIFM0069 HIF Info       Class Cytokine (Cyt)
             Description Prevotella bivia could induce higher levels exspression of CXCL2. [2]
          C-X-C motif chemokine 3
             HIF ID HIFM0070 HIF Info       Class Cytokine (Cyt)
             Description Prevotella bivia could induce higher levels expression of CXCL3. [2]
          Interleukin-1 alpha
             HIF ID HIFM0137 HIF Info       Class Cytokine (Cyt)
             Description Prevotella bivia could induce high expression levels of IL-1alpha. [2]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Prevotella bivia stimulate the release of interleukin1 (IL1) by dendritic cells (DC) through Tolllike receptor 2 (TLR2). [2]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description The increased IL8 levels in cervicovaginal fluid associated with the Prevotella bivia colonization. [2]
          CD44+ T helper cells
             HIF ID HIFC0155 HIF Info       Class T cells (TCs)
             Description Prevotella bivia could increase the number of CD44+ Th cells. [2]
          CCR5+ T helper cells
             HIF ID HIFC0182 HIF Info       Class T cells (TCs)
             Description Activated CCR5+ T helper cells increased in the vaginal tract of germ-free mice flowing inoculation with Prevotella bivia compared with Lactobacillus crispatus. [2]
Environmental Factor(s)
             Disbiome ID
      470
             gutMDisorder ID
      gm0535
References
1 Gardnerella vaginalis and Prevotella bivia Trigger Distinct and Overlapping Phenotypes in a Mouse Model of Bacterial Vaginosis. J Infect Dis. 2019 Aug 30;220(7):1099-1108. doi: 10.1093/infdis/jiy704.
2 The immune response to Prevotella bacteria in chronic inflammatory disease. Immunology. 2017 Aug;151(4):363-374. doi: 10.1111/imm.12760. Epub 2017 Jun 20.

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