Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0033)
HIF Name
C-C motif chemokine 5
HIF Synonym(s)
C-C motif chemokine ligand 5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP
HIF Classification
Cytokine (Cyt)
Molecular Function
Cytokine
Description Chemokines were originally described as cytokines that mediate leukocyte recruitment to sites of inflammation [1]
Pfam Small cytokines (intecrine/chemokine), interleukin-8 like (PF00048 )
Pathway Chagas disease (American trypanosomiasis) (hsa05142 )
Chemokine signaling pathway (hsa04062 )
Cytokine-cytokine receptor interaction (hsa04060 )
Cytosolic DNA-sensing pathway (hsa04623 )
Epithelial cell signaling in Helicobacter pylori infection (hsa05120 )
Herpes simplex virus 1 infection (hsa05168 )
Human cytomegalovirus infection (hsa05163 )
Influenza A (hsa05164 )
NOD-like receptor signaling pathway (hsa04621 )
Prion diseases (hsa05020 )
Rheumatoid arthritis (hsa05323 )
Shigellosis (hsa05131 )
TNF signaling pathway (hsa04668 )
Toll-like receptor signaling pathway (hsa04620 )
Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CCL5_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Clostridioides difficile (firmicutes) MIC00396
             Description RANTES propagated the inflammatory response to Clostridium difficile toxin A. [2]
         Prevotella bivia (CFB bacteria) MIC01007
             Description Prevotella bivia could induce higher levels of CCL5 expression. [3]
References
1 Cytokine CCL5 and receptor CCR5 axis in glioblastoma multiforme.Radiol Oncol. 2019 Nov 20;53(4):397-406. doi: 10.2478/raon-2019-0057.
2 TLR signaling in B-cell development and activation.Cell Mol Immunol. 2013 Mar;10(2):103-6. doi: 10.1038/cmi.2012.61. Epub 2012 Dec 17.
3 The immune response to Prevotella bacteria in chronic inflammatory disease. Immunology. 2017 Aug;151(4):363-374. doi: 10.1111/imm.12760. Epub 2017 Jun 20.

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