Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0070)
HIF Name
C-X-C motif chemokine 3
HIF Synonym(s)
C-X-C motif chemokine ligand 3, CINC-2b, GRO3, GROg, MIP-2b, MIP2B, SCYB3
HIF Classification
Cytokine (Cyt)
Molecular Function
Cytokine
Description CXCL13 is a potent chemoattractant of B cells. However, it can induce a weak chemotaxis in T cells and macrophages, with no activity towards neutrophils or monocytes. It has 87 amino acids (10.3 kDa). It is expressed in spleen, lymph nodes, liver, gut, and appendix. [1]
Pfam Small cytokines (intecrine/chemokine), interleukin-8 like (PF00048 )
Pathway Amoebiasis (hsa05146 )
Chemokine signaling pathway (hsa04062 )
Cytokine-cytokine receptor interaction (hsa04060 )
Epithelial cell signaling in Helicobacter pylori infection (hsa05120 )
IL-17 signaling pathway (hsa04657 )
Kaposi sarcoma-associated herpesvirus infection (hsa05167 )
Legionellosis (hsa05134 )
NF-kappa B signaling pathway (hsa04064 )
NOD-like receptor signaling pathway (hsa04621 )
Rheumatoid arthritis (hsa05323 )
TNF signaling pathway (hsa04668 )
Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CXCL3_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Lactobacillus buchneri (firmicutes) MIC00706
             Description The abundance of Lactobacillus buchneri DSM 32407 could lead endometrial mRNA expression of CXCL3. [2]
         Prevotella bivia (CFB bacteria) MIC01007
             Description Prevotella bivia could induce higher levels expression of CXCL3. [3]
References
1 Molecular cloning and biophysical characterization of CXCL3 chemokine.Int J Biol Macromol. 2018 Feb;107(Pt A):575-584. doi: 10.1016/j.ijbiomac.2017.09.032. Epub 2017 Sep 18.
2 Influence of intrauterine administration of Lactobacillus buchneri on reproductive performance and pro-inflammatory endometrial mRNA expression of cows with subclinical endometritis.Sci Rep. 2018 Apr 3;8(1):5473. doi: 10.1038/s41598-018-22856-y.
3 The immune response to Prevotella bacteria in chronic inflammatory disease. Immunology. 2017 Aug;151(4):363-374. doi: 10.1111/imm.12760. Epub 2017 Jun 20.

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