General Information of HIF (ID: HIFM0108)
HIF Name	Human granulysin
HIF Synonym(s)	Granulysin, GNLY, huGran, NKG5
HIF Classification	Antimicrobial peptide (AMP)
Molecular Function	Antibiotic; Antimicrobial; Fungicide
Description	Human granulysin has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]
Pfam	Saposin-like type B, region 2 (PF03489 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	GNLY_HUMAN
	APD ID	AP01160

Microbe Species (MIC) Regulated by This HIF
Mycobacterium tuberculosis (actinobacteria)			MIC00857
Description	Granulysin-dependent has enzymatic activity to kill of intracellular and extracellular Mycobacterium tuberculosis by V9/V2 T lymphocytes.				[2]
Pseudomonas aeruginosa (gamma-proteobacteria)			MIC01054
Description	Granulysin has effect on multidrug-resistant strains of Pseudomonas aeruginosa.				[3]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vgamma9/Vdelta2 T lymphocytes.J Infect Dis. 2001 Oct 15;184(8):1082-5. doi: 10.1086/323600. Epub 2001 Sep 28.
3	Synergistic effect of membrane-active peptides polymyxin B and gramicidin S on multidrug-resistant strains and biofilms of Pseudomonas aeruginosa.Antimicrob Agents Chemother. 2015 Sep;59(9):5288-96. doi: 10.1128/AAC.00682-15. Epub 2015 Jun 15.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.