Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0218)
HIF Name
Toll-like receptor 3
HIF Synonym(s)
toll like receptor 3, TLR3, CD283, IIAE2
HIF Classification
Toll-like receptor (TLR)
Molecular Function
Receptor; RNA-binding
Description TLR3 is a type I transmembrane protein [1]
Pfam Leucine Rich repeat (PF13516 )
Leucine rich repeat (PF13855 )
TIR domain (PF01582 )
Toll-like receptor 3 trans-membrane domain (PF17968 )
Pathway Hepatitis B (hsa05161 )
Hepatitis C (hsa05160 )
Herpes simplex virus 1 infection (hsa05168 )
Human papillomavirus infection (hsa05165 )
Influenza A (hsa05164 )
Kaposi sarcoma-associated herpesvirus infection (hsa05167 )
Necroptosis (hsa04217 )
Toll-like receptor signaling pathway (hsa04620 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
TLR3_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Moraxella catarrhalis (gamma-proteobacteria) MIC00837
             Description Moraxella catarrhalis decreases antiviral innate immune responses by down-regulation of TLR3 via inhibition of p53 in human bronchial epithelial cells. [2]
         Pseudomonas fluorescens (gamma-proteobacteria) MIC01056
             Description Pseudomonas fluorescens is associated with TLR-3 expression. [3]
References
1 Salivary epithelial cells from Sjogren's syndrome patients are highly sensitive to anoikis induced by TLR-3 ligation.J Autoimmun. 2010 Nov;35(3):212-8. doi: 10.1016/j.jaut.2010.06.010. Epub 2010 Aug 3.
2 Moraxella catarrhalis decreases antiviral innate immune responses by down-regulation of TLR3 via inhibition of p53 in human bronchial epithelial cells. FASEB J. 2016 Jun;30(6):2426-34. doi: 10.1096/fj.201500172R. Epub 2016 Mar 15.
3 Polyvalent protective immunogens identified from outer membrane proteins of Vibrio parahaemolyticus and their induced innate immune response. Fish Shellfish Immunol. 2018 Jan;72:104-110. doi: 10.1016/j.fsi.2017.10.046. Epub 2017 Oct 28.

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