General Information of HIF (ID: HIFM0057)
HIF Name	CEA cell adhesion molecule 1
HIF Synonym(s)	BGP-1, BGP, CEACAM, CEACAM-1
HIF Classification	Checkpoint molecule (CM)
Description	CEACAM1 is an immunoglobulin (Ig)-related glycoprotein, and serves as cellular receptor for a variety of Gram-negative bacterial pathogens associated with the human mucosa. In particular, Neisseria gonorrhoeae, N. meningitidis, Moraxella catarrhalis, and Haemophilus influenzae possess well-characterized CEACAM1-binding adhesins. CEACAM1 is typically involved in cell-cell attachment, epithelial differentiation, neovascularisation and regulation of T-cell proliferation, and is one of the few CEACAM family members with homologues in different mammalian lineages.				[1]
Pfam	Immunoglobulin V-set domain (PF07686 )
	Immunoglobulin domain (PF00047 )
	Immunoglobulin domain (PF13895 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	CEAM1_HUMAN

Microbe Species (MIC) Regulated by This HIF
Candida albicans (budding yeasts)			MIC00317
Description	The expression of human CEACAM1 does not influence the intestinal colonization by Candida albicans in human CEACAM1-transgenic mice(p=0.912).				[2]
Citrobacter rodentium (enterobacteria)			MIC00366
Description	The expression of CEACAM1 can determine the host susceptibility to Citrobacter rodentium infection.				[3]
Escherichia coli (enterobacteria)			MIC00516
Description	CEACAM1 serves as a receptor for Escherichia coli pathogens in humans.				[4]
Fusobacterium nucleatum (fusobacteria)			MIC00617
Description	Fusobacterium nucleatum has a strong enzymatic activity which can bind and activates CEACAM1 leading to the inhibition of immune cell activities.				[5]
Haemophilus influenzae (gamma-proteobacteria)			MIC00652
Description	CEACAM1 serves as a receptor for Haemophilus influenzae pathogens in humans.				[4]
Helicobacter pylori (epsilon-proteobacteria)			MIC00669
Description	CEACAM1 serves as a receptor for Helicobacter pylori pathogens in humans.				[4]
Listeria monocytogenes (firmicutes)			MIC00771
Description	The predominance of the CEACAM1-S isoform requires persistent exposure to mucosal antigens such as Listeria monocytogenes.				[4]
Moraxella catarrhalis (gamma-proteobacteria)			MIC00837
Description	CEACAM1 serves as a receptor for Moraxella catarrhalis pathogens in humans.				[4]
Neisseria gonorrhoeae (beta-proteobacteria)			MIC00885
Description	CEACAM1 serves as a receptor for Neisseria gonorrhoeae pathogens in humans.				[4]
Neisseria meningitidis (beta-proteobacteria)			MIC00891
Description	CEACAM1 serves as a receptor for Neisseria meningitidis pathogens in humans.				[4]
Salmonella sp. (enterobacteria)			MIC01149
Description	CEACAM1 serves as a receptor for Salmonella pathogens in humans.				[4]

References
1	CEACAM1 recognition by bacterial pathogens is species-specific.BMC Microbiol. 2010 Apr 20;10:117. doi: 10.1186/1471-2180-10-117.
2	Unaltered Fungal Burden and Lethality in Human CEACAM1-Transgenic Mice During Candida albicans Dissemination and Systemic Infection.Front Microbiol. 2019 Nov 26;10:2703. doi: 10.3389/fmicb.2019.02703. eCollection 2019.
3	CEACAM1 regulates CD8(+) T cell immunity and protects from severe pathology during Citrobacter rodentium induced colitis.Gut Microbes. 2020 Nov 1;11(6):1790-1805. doi: 10.1080/19490976.2020.1775464. Epub 2020 Jun 10.
4	CEACAM1 in Liver Injury, Metabolic and Immune Regulation.Int J Mol Sci. 2018 Oct 11;19(10):3110. doi: 10.3390/ijms19103110.
5	Fusobacterium nucleatum supresses anti-tumor immunity by activating CEACAM1.Oncoimmunology. 2019 Mar 27;8(6):e1581531. doi: 10.1080/2162402X.2019.1581531. eCollection 2019.

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