Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00885)
MIC Name Neisseria gonorrhoeae (beta-proteobacteria)
MIC Synonyms Merismopedia gonorrhoeae
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Neisseriales
Family: Neisseriaceae
Genus: Neisseria
Species: Neisseria gonorrhoeae
Oxygen Sensitivity Aerobe
Microbial Metabolism Oxidative; Saccharolytic
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 2173235
No. of Coding Genes 2209
No. of Non-Coding Genes 50
No. of Small Non-Coding Genes 50
No. of Gene Transcripts 2259
No. of Base Pairs 2151002
Description Neisseria gonorrhoeae is an aerobic, Gram negative, non-motile, non-spore-forming diplococcus bacterium and a member of the family Neisseriaceae of the subclass of the class Proteobacteria. Neisseria gonorrhoeae infections are acquired by sexual contact and usually affect the mucous membranes of the urethra in males and the endocervix and urethra in females.
External Links Taxonomy ID
485
Genome Assembly ID
NG-e03.04
GOLD Organism ID
Go0042337
Disease Relevance
          Female pelvic inflammatory disease  [ICD-11: GA05]
             Description Neisseria gonorrhoeae is one of the main etiological agents of sexually transmitted diseases. The asymptomatic course of the infection and its resistance to antibiotics can lead to pelvic inflammatory disease. [1]
          Infertility  [ICD-11: GA31]
             Description Neisseria gonorrhoeae is one of the main etiological agents of sexually transmitted diseases. The asymptomatic course of the infection and its resistance to antibiotics can lead to infertility. [1]
          Meningococcal disease  [ICD-11: 1C1C]
             Description The host-adapted human pathogen Neisseria gonorrhoeae is the causative agent of gonorrhoea. [2]
Host Genetic Factors (HGFs)
          rs62196761
             HGF ID HGF1595 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs62196761 SNP was significantly associated with the abundance of Neisseria gonorrhoeae (p-value<1.00E-08). [3]
Host Immune Factors (HIFs)
          HE2alpha
             HIF ID HIFM0291 HIF Info       Class Antimicrobial peptide (AMP)
             Description The HE2alpha peptide could kill or inactivate Neisseria gonorrhoeae(deactivate enzymatic activity) rapidly through different mechanisms and exhibited time- and dose-dependent antibacterial effects on all Neisseria gonorrhoeae isolates tested. [4]
          CEA cell adhesion molecule 1
             HIF ID HIFM0057 HIF Info       Class Checkpoint molecule (CM)
             Description CEACAM1 serves as a receptor for Neisseria gonorrhoeae pathogens in humans. [5]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description Neisseria gonorrhoeae could induce IgG responce. [6]
          Immunoglobulin A1
             HIF ID HIFM0275 HIF Info       Class Immunoglobulin (Ig)
             Description The activity of IgA1 proteases from Neisseria gonorrhoeae could effect enzymolysis of human immunoglobulin A1(lgA1). [7]
          CD4+ regulatory T cells
             HIF ID HIFC0034 HIF Info       Class T cells (TCs)
             Description Greater CD4+ T cell responses was elicited by oral immunization with the ghost vaccine candidate than Neisseria gonorrhoeae DNA vaccine alone. [6]
          CD8+ T cells
             HIF ID HIFC0073 HIF Info       Class T cells (TCs)
             Description Greater CD8+ T cell responses was elicited by oral immunization with the ghost vaccine candidate than Neisseria gonorrhoeae DNA vaccine alone. [6]
Environmental Factor(s)
             Disbiome ID
      1050
             gutMDisorder ID
      gm0466
References
1 Use of the mtrR Gene for Rapid Molecular Diagnosis of Neisseria gonorrhoeae and Identification of the Reduction of Susceptibility to Antibiotics in Endocervical Swabs. Mol Diagn Ther. 2018 Jun;22(3):361-368. doi: 10.1007/s40291-018-0328-x.
2 Neisseria gonorrhoeae host adaptation and pathogenesis. Nat Rev Microbiol. 2018 Apr;16(4):226-240. doi: 10.1038/nrmicro.2017.169. Epub 2018 Feb 12.
3 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
4 Cationic peptide of the male reproductive tract, HE2alpha, displays antimicrobial activity against Neisseria gonorrhoeae, Staphylococcus aureus and Enterococcus faecalis.J Antimicrob Chemother. 2005 Nov;56(5):957-61. doi: 10.1093/jac/dki350. Epub 2005 Sep 29.
5 CEACAM1 in Liver Injury, Metabolic and Immune Regulation.Int J Mol Sci. 2018 Oct 11;19(10):3110. doi: 10.3390/ijms19103110.
6 Design and immune characterization of a novel Neisseria gonorrhoeae DNA vaccine using bacterial ghosts as vector and adjuvant. Vaccine. 2018 Jul 16;36(30):4532-4539. doi: 10.1016/j.vaccine.2018.06.006. Epub 2018 Jun 18.
7 Effect of mutations in the human immunoglobulin A1 (IgA1) hinge on its susceptibility to cleavage by diverse bacterial IgA1 proteases.Infect Immun. 2005 Mar;73(3):1515-22. doi: 10.1128/IAI.73.3.1515-1522.2005.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.