General Information of HIF (ID: HIFM0291)
HIF Name	HE2alpha
HIF Synonym(s)	He2alpha
HIF Classification	Antimicrobial peptide (AMP)
Description	HE2alpha has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]
External Links
	APD ID	AP02891

Microbe Species (MIC) Regulated by This HIF
Enterococcus faecalis (firmicutes)			MIC00548
Description	Enterococcus faecalis strains are susceptible to the HE2alpha peptide.				[2]
Neisseria gonorrhoeae (beta-proteobacteria)			MIC00885
Description	The HE2alpha peptide could kill or inactivate Neisseria gonorrhoeae(deactivate enzymatic activity) rapidly through different mechanisms and exhibited time- and dose-dependent antibacterial effects on all Neisseria gonorrhoeae isolates tested.				[2]
Staphylococcus aureus (firmicutes)			MIC01208
Description	Staphylococcus aureus is susceptible to the HE2alpha peptide.				[2]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	Cationic peptide of the male reproductive tract, HE2alpha, displays antimicrobial activity against Neisseria gonorrhoeae, Staphylococcus aureus and Enterococcus faecalis.J Antimicrob Chemother. 2005 Nov;56(5):957-61. doi: 10.1093/jac/dki350. Epub 2005 Sep 29.

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