General Information of HIF (ID: HIFM0127)
HIF Name	Interferon lambda
HIF Synonym(s)	Interferon lambda, IFNL
HIF Classification	Cytokine (Cyt)
Molecular Function	Cytokine
Description	Lambda Interferon (IFN-), a Type III IFN, Is Induced by Viruses and IFNs and Displays Potent Antiviral Activity against Select Virus Infections In Vivo				[1]
Pfam	Interleukin-28A (PF15177 )
Pathway	Cytokine-cytokine receptor interaction (hsa04060 )
	JAK-STAT signaling pathway (hsa04630 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	IFNL1_HUMAN

Microbe Species (MIC) Regulated by This HIF
Moraxella catarrhalis (gamma-proteobacteria)			MIC00837
Description	Moraxella catarrhalis diminished the TLR3-dependent secretion of IFN through reducing enzyme activity.				[2]

References
1	Lambda interferon (IFN-lambda), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo.J Virol. 2006 May;80(9):4501-9. doi: 10.1128/JVI.80.9.4501-4509.2006.
2	Moraxella catarrhalis decreases antiviral innate immune responses by down-regulation of TLR3 via inhibition of p53 in human bronchial epithelial cells. FASEB J. 2016 Jun;30(6):2426-34. doi: 10.1096/fj.201500172R. Epub 2016 Mar 15.

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