General Information of MIC (ID: MIC00475)
MIC Name	Cyanobacteria (cyanobacteria)
MIC Synonyms	Cyanophyceae; Cyanophycota; Cyanophyta; Oxygenic photosynthetic bacteria
Body Site	Blood
Lineage	Kingdom: Bacteria Phylum: Cyanobacteria
Oxygen Sensitivity	Aerobe
Microbial Metabolism	Respiratory
Gram	Negative
Description	Cyanobacteria, also known as Cyanophyta, is a phylum consisting of free-living photosynthetic bacteria and the endosymbiotic plastids, a sister group to Gloeomargarita, that are present in some eukaryotes.
External Links	Taxonomy ID	1117

Host Genetic Factors (HGFs)
hsa-miR-200a-3p
HGF ID	HGF0213	HGF Info	Class	Non-coding RNA: Micro (ncRNA-miRNA)
Description	The level of miR-200a-3p was substantially correlated with the relative abundance of Cyanobacteria.				[1]
rs9421681
HGF ID	HGF2265	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs9421681 SNP was significantly associated with the relative abundance of Cyanobacteria (p-value=1.07E-08).				[2]
rs516246
HGF ID	HGF1582	HGF Info	Class	Single Nucleotide Polymorphism: Non coding transcript variant (SNP-NCTV)
Description	The rs516246 SNP was significantly associated with the abundance of Cyanobacteria (p-value=0.01641).				[3]

Host Immune Factors (HIFs)
C-C motif chemokine 3
HIF ID	HIFM0031	HIF Info	Class	Cytokine (Cyt)
Description	At the phylum level, Cyanobacteria is associated with the CCL3 expression.				[4]
C-X-C motif chemokine 2
HIF ID	HIFM0069	HIF Info	Class	Cytokine (Cyt)
Description	At the phylum level, Cyanobacteria is associated with CXCL-2 expression.				[4]
C-X-C motif chemokine 1
HIF ID	HIFM0109	HIF Info	Class	Cytokine (Cyt)
Description	At the phylum level, Cyanobacteria is associated with the CXCL-1 expression.				[4]
Interferon-10
HIF ID	HIFM0128	HIF Info	Class	Cytokine (Cyt)
Description	The Cyanobacteria could induce the significant release of pro-inflammatory cytokines IL-10(p < 0.05).				[4]
Interleukin-1 beta
HIF ID	HIFM0138	HIF Info	Class	Cytokine (Cyt)
Description	Cyanobacteria is associated with IL-1beta expression.				[4]
Interferon-6
HIF ID	HIFM0151	HIF Info	Class	Cytokine (Cyt)
Description	Cyanobacteria is associated with IL-6 expression.				[4]
Tumor necrosis factor
HIF ID	HIFM0226	HIF Info	Class	Cytokine (Cyt)
Description	At the phylum level, Cyanobacteria is associated with tnF-Alpha.				[4]
Macrophage inflammatory protein 1
HIF ID	HIFM0242	HIF Info	Class	Cytokine (Cyt)
Description	At the phylum level, Cyanobacteria is associated with MIP-2.				[4]
Cindoxin
HIF ID	HIFM0258	HIF Info	Class	Cytokine (Cyt)
Description	At the phylum level, Cyanobacteria is associated with CINC-1.				[4]
Monocytes
HIF ID	HIFC0024	HIF Info	Class	Monocytes (Mono)
Description	Lipopolysaccharide isolated from complex water bloom dominated by Cyanobacteria revealed the priming of both major blood phagocyte population monocytes.				[4]

Environmental Factor(s)
Disbiome ID			533
gutMDisorder ID			gm0236

References
1	Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1. Vikram A, Kim YR, Kumar S, Li Q, Kassan M, Jacobs JS, Irani K.. Nat Commun. 2016 Sep 2;7:12565. doi: 10.1038/ncomms12565.
2	Association of host genome with intestinal microbial composition in a large healthy cohort.Nat Genet. 2016 Nov;48(11):1413-1417. doi: 10.1038/ng.3693. Epub 2016 Oct 3.
3	FUT2 genotype and secretory status are not associated with fecal microbial composition and inferred function in healthy subjects.Gut Microbes. 2018 Jul 4;9(4):357-368. doi: 10.1080/19490976.2018.1445956. Epub 2018 Apr 27.
4	Lipopolysaccharides from Microcystis Cyanobacteria-Dominated Water Bloom and from Laboratory Cultures Trigger Human Immune Innate Response. Toxins (Basel). 2019 Apr 11;11(4):218. doi: 10.3390/toxins11040218.

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