Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0031)
HIF Name	C-C motif chemokine 3
HIF Synonym(s)	C-C motif chemokine ligand 3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3
HIF Classification	Cytokine (Cyt)
Molecular Function	Cytokine
Description	Chemokines were originally described as cytokines that mediate leukocyte recruitment to sites of inflammation		[1]
Pfam	Small cytokines (intecrine/chemokine), interleukin-8 like (PF00048 )
Pathway	Chagas disease (American trypanosomiasis) (hsa05142 )
	Chemokine signaling pathway (hsa04062 )
	Cytokine-cytokine receptor interaction (hsa04060 )
	Human cytomegalovirus infection (hsa05163 )
	Rheumatoid arthritis (hsa05323 )
	Toll-like receptor signaling pathway (hsa04620 )
	Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
External Links	Uniprot ID	CCL3_HUMAN

Microbe Species (MIC) Regulated by This HIF
Cyanobacteria (cyanobacteria)		MIC00475
Description	At the phylum level, Cyanobacteria is associated with the CCL3 expression.		[2]

References
1	Inhibition of CCL3 abrogated precursor cell fusion and bone erosions in human osteoclast cultures and murine collagen-induced arthritis.Rheumatology (Oxford). 2018 Nov 1;57(11):2042-2052. doi: 10.1093/rheumatology/key196.
2	Lipopolysaccharides from Microcystis Cyanobacteria-Dominated Water Bloom and from Laboratory Cultures Trigger Human Immune Innate Response. Toxins (Basel). 2019 Apr 11;11(4):218. doi: 10.3390/toxins11040218.

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