General Information of HIF (ID: HIFM0109)
HIF Name	C-X-C motif chemokine 1
HIF Synonym(s)	C-X-C motif chemokine ligand
HIF Classification	Cytokine (Cyt)
Molecular Function	Cytokine; Growth factor
Description	CXCL1 is part of a gene signature associated with recurrent lung metastasis in mammary tumor models (Minn et al., 2007, 2005). CXCL1 increases invasiveness of circulating tumor cells (Kim et al., 2009). Knockdown of CXCL1 in breast cancer cells inhibits lung metastasis of mammary carcinoma cells in tail vein injection models				[1]
Pfam	Small cytokines (intecrine/chemokine), interleukin-8 like (PF00048 )
Pathway	Amoebiasis (hsa05146 )
	Chemokine signaling pathway (hsa04062 )
	Cytokine-cytokine receptor interaction (hsa04060 )
	Epithelial cell signaling in Helicobacter pylori infection (hsa05120 )
	IL-17 signaling pathway (hsa04657 )
	Kaposi sarcoma-associated herpesvirus infection (hsa05167 )
	Legionellosis (hsa05134 )
	NF-kappa B signaling pathway (hsa04064 )
	NOD-like receptor signaling pathway (hsa04621 )
	Rheumatoid arthritis (hsa05323 )
	TNF signaling pathway (hsa04668 )
	Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	GROA_HUMAN

Microbe Species (MIC) Regulated by This HIF
Aggregatibacter aphrophilus (gamma-proteobacteria)			MIC00052
Description	At the genus level, Aggregatibacter is associated with CXCL1 expression.				[2]
Bacillus firmus (firmicutes)			MIC00127
Description	The abundance of Bacilli was associated with the CXCL-1 expression.				[3]
Burkholderia pseudomallei (beta-proteobacteria)			MIC00287
Description	The expression of KC significantly increased during Burkholderia pseudomallei infection.				[4]
Chlamydia pneumoniae (chlamydias)			MIC00350
Description	Chlamydophila pneumoniae is associated with chemokine C-X-C motif ligand 1 (CXCL1) expression.				[5]
Citrobacter rodentium (enterobacteria)			MIC00366
Description	The expression of CXCL1 is particularly highly induced during Citrobacter rodentium infection.				[6]
Cyanobacteria (cyanobacteria)			MIC00475
Description	At the phylum level, Cyanobacteria is associated with the CXCL-1 expression.				[7]
Escherichia coli (enterobacteria)			MIC00516
Description	Basolateral Escherichia coli infection induced about 60-fold increase in CXCL1 transcription.				[6]
Klebsiella pneumoniae (enterobacteria)			MIC01405
Description	There is a decreased survival in the CXCL1/ group and only 14.3% of mice survived after 15 days with Klebsiella pneumoniae infection(103 CFU/mouse).				[6]
Lactobacillus reuteri (firmicutes)			MIC00731
Description	Lactobacillus reuteri could decrease the level of cytokines KC.				[8]
Yersinia pestis (enterobacteria)			MIC01401
Description	There is no significant changes observed in the lungs in the levels of the major neutrophil chemoattractant CXCL1 after pulmonary infection with a fully virulent Yersinia pestis strain.				[9]

References
1	CXCL1/CXCR2 signaling in pathological pain: Role in peripheral and central sensitization.Neurobiol Dis. 2017 Sep;105:109-116. doi: 10.1016/j.nbd.2017.06.001. Epub 2017 Jun 3.
2	Commensal and pathogenic biofilms differently modulate peri-implant oral mucosa in an organotypic model. Cell Microbiol. 2019 Oct;21(10):e13078. doi: 10.1111/cmi.13078. Epub 2019 Jul 17.
3	Cording Mycobacterium tuberculosis Bacilli Have a Key Role in the Progression towards Active Tuberculosis, Which is Stopped by Previous Immune Response. Microorganisms. 2020 Feb 8;8(2):228. doi: 10.3390/microorganisms8020228.
4	Dysregulation of TNF- and IFN- expression is a common host immune response in a chronically infected mouse model of melioidosis when comparing multiple human strains of Burkholderia pseudomallei. BMC Immunol. 2020 Feb 3;21(1):5. doi: 10.1186/s12865-020-0333-9.
5	Chlamydia pneumoniae Infection and Inflammatory Diseases. For Immunopathol Dis Therap. 2016;7(3-4):237-254. doi: 10.1615/ForumImmunDisTher.2017020161.
6	Interleukin-8, CXCL1, and MicroRNA miR-146a Responses to Probiotic Escherichia coli Nissle 1917 and Enteropathogenic E. coli in Human Intestinal Epithelial T84 and Monocytic THP-1 Cells after Apical or Basolateral Infection.Infect Immun. 2016 Aug 19;84(9):2482-92. doi: 10.1128/IAI.00402-16. Print 2016 Sep.
7	Lipopolysaccharides from Microcystis Cyanobacteria-Dominated Water Bloom and from Laboratory Cultures Trigger Human Immune Innate Response. Toxins (Basel). 2019 Apr 11;11(4):218. doi: 10.3390/toxins11040218.
8	Probiotics Lactobacillus reuteri Abrogates Immune Checkpoint Blockade-Associated Colitis by Inhibiting Group 3 Innate Lymphoid Cells. Front Immunol. 2019 Jun 4;10:1235. doi: 10.3389/fimmu.2019.01235. eCollection 2019.
9	Immunology of Yersinia pestis Infection. Adv Exp Med Biol. 2016;918:273-292. doi: 10.1007/978-94-024-0890-4_10.

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