Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00287)
MIC Name Burkholderia pseudomallei (beta-proteobacteria)
MIC Synonyms Bacillus pseudomallei
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Burkholderiaceae
Genus: Burkholderia
Species: Burkholderia pseudomallei
Oxygen Sensitivity Aerobe
Microbial Metabolism Glycolysis; Krebs Cycle; Pentose phosphate pathways; Fermentative
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 7202363
No. of Coding Genes 5571
No. of Non-Coding Genes 106
No. of Small Non-Coding Genes 106
No. of Gene Transcripts 5807
No. of Pseudogenes 130
No. of Base Pairs 7161655
Description Burkholderia pseudomallei is a Gram-negative, bipolar, aerobic, motile rod-shaped bacterium. It infects humans and animals and causes the disease melioidosis. It is also capable of infecting plants.
External Links Taxonomy ID
28450
Genome Assembly ID
BP_3921g
GOLD Organism ID
Go0520812
Disease Relevance
          Autism spectrum disorder  [ICD-11: 6A02]
             Description The genus Burkholderia was significantly increased in autistic participants compared to controls. [1]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Burkholderia pseudomallei is associated with inflammatory bowel disease. [2]
Host Genetic Factors (HGFs)
          hsa-miR-4755-5p
             HGF ID HGF0550 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-4755-5p was 6.04-fold up-regulation in Burkholderia pseudomallei. [3]
          hsa-miR-4688
             HGF ID HGF0549 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-4688 was 2.01-fold up-regulated in Burkholderia pseudomallei. [3]
          hsa-miR-4662a-3p
             HGF ID HGF0548 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-4662a-3p was 2.01-fold up-regulated in Burkholderia pseudomallei. [3]
          hsa-miR-4651
             HGF ID HGF0547 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-4651 was 4.20-fold down-regulated in Burkholderia pseudomallei. [3]
          hsa-miR-3613-3p
             HGF ID HGF0538 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-3613-3p was 1.59-fold down-regulated in Burkholderia pseudomallei-exposed human peripheral blood mononuclear cells. [3]
          hsa-miR-127-5p
             HGF ID HGF0528 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-127-5p was 4.20-fold down-regulated in Burkholderia pseudomallei. [3]
          hsa-miR-3161
             HGF ID HGF2664 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-3161 was 3.93-fold down-regulated in Burkholderia pseudomallei. [3]
          hsa-let-7d-5p
             HGF ID HGF0299 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-let-7d-5p was significantly up-regulated in Burkholderia pseudomallei-exposed human peripheral blood mononuclear cells (p-value<0.05). [3]
          hsa-miR-10b-5p
             HGF ID HGF0285 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-10b-5p was 2.32-fold up-regulated in Burkholderia pseudomallei. [3]
          hsa-miR-1226-3p
             HGF ID HGF0284 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-1226-3p was significantly up-regulated in Burkholderia pseudomallei-exposed human peripheral blood mononuclear cells (p-value <0.05). [3]
          hsa-miR-125b-2-3p
             HGF ID HGF0277 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-125b-2-3p was 3.89-fold down-regulated in Burkholderia pseudomallei-exposed human peripheral blood mononuclear cells. [3]
          hsa-miR-135b-5p
             HGF ID HGF0264 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-135b-5p was 2.01-fold up-regulated in Burkholderia pseudomallei. [3]
          hsa-miR-146a-5p
             HGF ID HGF0252 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-96-5p was 1.313-fold down-regulated in Burkholderia pseudomallei. [3]
          hsa-miR-196b-3p
             HGF ID HGF0220 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-196b-3p was 3.93-fold down-regulated in Burkholderia pseudomallei. [3]
          hsa-miR-4507
             HGF ID HGF2666 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-4507 was 3.93-fold down-regulated in Burkholderia pseudomallei. [3]
          hsa-miR-200b-3p
             HGF ID HGF0212 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-200b-3p was 2.26-fold up-regulated in Burkholderia pseudomallei. [3]
          hsa-miR-4682
             HGF ID HGF2667 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-4682 was 3.93-fold down-regulated in Burkholderia pseudomallei. [3]
          hsa-miR-23b-5p
             HGF ID HGF0189 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-23b-5p was significantly up-regulated in Burkholderia pseudomallei-exposed human peripheral blood mononuclear cells (p-value=0.0136). [3]
          hsa-miR-3074-3p
             HGF ID HGF0169 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-3074-3p was 2.45-fold up-regulated in Burkholderia pseudomallei. [3]
          hsa-miR-30c-5p
             HGF ID HGF0166 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-30c-5p may be upregulated to control caspase-3 expression in Burkholderia pseudomallei-exposed human peripheral blood mononuclear cells. [3]
          hsa-miR-3177-3p
             HGF ID HGF0161 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-3177-3p was 2.06-fold up-regulated in Burkholderia pseudomallei. [3]
          hsa-miR-2114-5p
             HGF ID HGF2668 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-2114-5p was 3.89-fold down-regulated in Burkholderia pseudomallei. [3]
Host Immune Factors (HIFs)
          C-X-C motif chemokine 9
             HIF ID HIFM0073 HIF Info       Class Cytokine (Cyt)
             Description The expression of MIG significantly increased during Burkholderia pseudomallei infection. [4]
          C-X-C motif chemokine 1
             HIF ID HIFM0109 HIF Info       Class Cytokine (Cyt)
             Description The expression of KC significantly increased during Burkholderia pseudomallei infection. [4]
          Interleukin-1 alpha
             HIF ID HIFM0137 HIF Info       Class Cytokine (Cyt)
             Description Increased expression of IL-1alpha was confined primarily to the area with the pathogen Burkholderia pseudomallei within pyogranulomatous lesions. [4]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Increased expression of IL-1beta was confined primarily to the area with the pathogen Burkholderia pseudomallei within pyogranulomatous lesions. [4]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Increased expression of proinflammatory cytokines TNF-alpha was confined primarily to the area with the pathogen Burkholderia pseudomallei within pyogranulomatous lesions. [4]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description Increased expression of proinflammatory cytokines IFN-gamma was confined primarily to the area with the pathogen Burkholderia pseudomallei within pyogranulomatous lesions. [4]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description Sera from mice with enlarged spleens exhibited moderate IgG titers against Burkholderia pseudomallei. [4]
Environmental Factor(s)
             Disbiome ID
      371
             gutMDisorder ID
      gm0131
             aBiofilm Organism
      Burkholderia pseudomallei
References
1 The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder. Int J Mol Sci. 2019 Apr 29;20(9):2115. doi: 10.3390/ijms20092115.
2 Host immunoglobulin G selectively identifies pathobionts in pediatric inflammatory bowel diseases. Microbiome. 2019 Jan 3;7(1):1. doi: 10.1186/s40168-018-0604-3.
3 Differential MicroRNA Analyses of Burkholderia pseudomallei- and Francisella tularensis-Exposed hPBMCs Reveal Potential Biomarkers. Int J Genomics. 2017;2017:6489383. doi: 10.1155/2017/6489383. Epub 2017 Jul 16.
4 Dysregulation of TNF- and IFN- expression is a common host immune response in a chronically infected mouse model of melioidosis when comparing multiple human strains of Burkholderia pseudomallei. BMC Immunol. 2020 Feb 3;21(1):5. doi: 10.1186/s12865-020-0333-9.

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