Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0073)
HIF Name
C-X-C motif chemokine 9
HIF Synonym(s)
C-X-C motif chemokine ligand 9, CMK, Humig, MIG, SCYB9, crg-10
HIF Classification
Cytokine (Cyt)
Molecular Function
Cytokine
Description CXCL9 (C-X-C Motif Chemokine Ligand 9) is a Protein Coding gene. Diseases associated with CXCL9 include Proliferative Glomerulonephritis and Paracoccidioidomycosis. Among its related pathways are Signaling by GPCR and CCR5 Pathway in Macrophages. [1]
Pfam Small cytokines (intecrine/chemokine), interleukin-8 like (PF00048 )
Pathway Chemokine signaling pathway (hsa04062 )
Cytokine-cytokine receptor interaction (hsa04060 )
Toll-like receptor signaling pathway (hsa04620 )
Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CXCL9_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Burkholderia pseudomallei (beta-proteobacteria) MIC00287
             Description The expression of MIG significantly increased during Burkholderia pseudomallei infection. [2]
         Campylobacter coli (epsilon-proteobacteria) MIC00301
             Description Campylobacter which was among the gingivitis biomarkers in the MiG(Cxcl9) model. [3]
         Lactobacillus iners (firmicutes) MIC00719
             Description The abundance of Lactobacillus iners was clustered with genital levels of MIG(Cxcl9). [4]
         Lactobacillus plantarum (firmicutes) MIC00730
             Description The cirrhotic complications induced by TAA are through activation of CXCL9 pathway and could be prevented by the early administration of Lactobacillus Plantarum. [5]
         Selenomonas artemidis (firmicutes) MIC01164
             Description Selenomonas which was among the gingivitis biomarkers in the MiG(Cxcl9) model. [3]
         Treponema pallidum (spirochaetes) MIC01325
             Description Treponema is the gingivitis biomarker in the MiG(Cxcl9) model, were among the major donors of flagellar biosynthesis pathways in the plaque microbiota of periodontal disease. [3]
References
1 CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation - A target for novel cancer therapy.Cancer Treat Rev. 2018 Feb;63:40-47. doi: 10.1016/j.ctrv.2017.11.007. Epub 2017 Nov 26.
2 Dysregulation of TNF- and IFN- expression is a common host immune response in a chronically infected mouse model of melioidosis when comparing multiple human strains of Burkholderia pseudomallei. BMC Immunol. 2020 Feb 3;21(1):5. doi: 10.1186/s12865-020-0333-9.
3 Predictive modeling of gingivitis severity and susceptibility via oral microbiota.ISME J. 2014 Sep;8(9):1768-80. doi: 10.1038/ismej.2014.32. Epub 2014 Mar 20.
4 Impact of Standard Bacterial Vaginosis Treatment on the Genital Microbiota, Immune Milieu, and Ex Vivo Human Immunodeficiency Virus Susceptibility.Clin Infect Dis. 2019 May 2;68(10):1675-1683. doi: 10.1093/cid/ciy762.
5 Involvement of TLR4/ CXCL9/ PREX-2 pathway in the development of hepatocellular carcinoma (HCC) and the promising role of early administration of lactobacillus plantarum in Wistar rats.Tissue Cell. 2019 Oct;60:38-47. doi: 10.1016/j.tice.2019.07.010. Epub 2019 Jul 31.

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