Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00719)
MIC Name Lactobacillus iners (firmicutes)
MIC Synonyms Lactobacillus sp. 7_1_47FAA
Body Site Vagina
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus iners
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Host Relationship Probiotic
Genome Size (bp) 1277649
Description Lactobacillus iners is a rod-shaped facultative anaerobic non-spore forming Gram-positive bacteria. It is a common member of human-associated bacterial microflora. Along with L. gasseri, L. crispatus, and L. jensenii, it is considered to be one of the four major vaginal Lactobacillus species.
External Links Taxonomy ID
147802
Genome Assembly ID
ASM18540v1
GOLD Organism ID
Go0003636
Disease Relevance
          Behcet disease  [ICD-11: 4A62]
             Description The abundance of Lactobacillus iners increased significantly in patients with Behcet's disease. [1]
          Rheumatoid arthritis  [ICD-11: FA20]
             Description Lactobacillus iners is upregulated in rheumatoid arthritis. [2]
Host Genetic Factors (HGFs)
          hsa-miR-146a-5p
             HGF ID HGF0252 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-146 expression by Lactobacillus iners bacteria-free supernatants with no expression change. [3]
          hsa-miR-193b-3p
             HGF ID HGF0223 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-193b expression was positively associated with vaginal microbiota dominated by a Lactobacillus species. [4]
          hsa-miR-223-3p
             HGF ID HGF0194 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-223 was best able to predict the relative abundance of Lactobacillus spp. [4]
          rs527430
             HGF ID HGF2636 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The most significant SNP associated with relative abundance of Lactobacillus iners was rs527430 on chromosome 1. [5]
          rs77007265
             HGF ID HGF2637 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-NCTV)
             Description The single nucleotide polymorphisms rs77007265 is associated with the abundance of vaginal microbiome Lactobacillus iners. [5]
          rs17010778
             HGF ID HGF2638 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-NCTV)
             Description The single nucleotide polymorphisms rs17010778 associated with the abundance of vaginal microbiome Lactobacillus iners. [5]
          rs12221275
             HGF ID HGF2639 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The single nucleotide polymorphisms rs12221275 associated with the abundance of vaginal microbiome Lactobacillus iners. [5]
Host Immune Factors (HIFs)
          Secretory leukocyte protease inhibitor
             HIF ID HIFM0208 HIF Info       Class Antimicrobial peptide (AMP)
             Description A strong positively correlation was observed between Lactobacillus iners and SLPI. [6]
          C-X-C motif chemokine 9
             HIF ID HIFM0073 HIF Info       Class Cytokine (Cyt)
             Description The abundance of Lactobacillus iners was clustered with genital levels of MIG(Cxcl9). [7]
Environmental Factor(s)
             Disbiome ID
      387
             gutMDisorder ID
      gm0393
References
1 Relative abundance of Megamonas hypermegale and Butyrivibrio species decreased in the intestine and its possible association with the T cell aberration by metabolite alteration in patients with Behcet's disease (210 characters). Clin Rheumatol. 2019 May;38(5):1437-1445. doi: 10.1007/s10067-018-04419-8. Epub 2019 Jan 9.
2 Intestinal Lactobacillus in health and disease, a driver or just along for the ride. Curr Opin Biotechnol. 2018 Feb;49:140-147. doi: 10.1016/j.copbio.2017.08.004. Epub 2017 Sep 1.
3 Gut Microbiota and Endothelial Dysfunction Markers in Obese Mexican Children and Adolescents. Nirmalkar K, Murugesan S, Pizano-Zrate ML, Villalobos-Flores LE, Garca-Gonzlez C, Morales-Hernndez RM, Nuez-Hernndez JA, Hernndez-Quiroz F, Romero-Figueroa MDS, Hernndez-Guerrero C, Hoyo-Vadillo C, Garca-Mena J.. Nutrients. 2018 Dec 19;10(12):2009. doi: 10.3390/nu10122009.
4 Common Cervicovaginal Microbial Supernatants Alter Cervical Epithelial Function: Mechanisms by Which Lactobacillus crispatus Contributes to Cervical Health. Anton L, Sierra LJ, DeVine A, Barila G, Heiser L, Brown AG, Elovitz MA.. Front Microbiol. 2018 Oct 8;9:2181. doi: 10.3389/fmicb.2018.02181. eCollection 2018.
5 Archaic Hominin Introgression in Africa Contributes to Functional Salivary MUC7 Genetic Variation. Mol Biol Evol. 2017 Oct 1;34(10):2704-2715. doi: 10.1093/molbev/msx206.
6 The lower genital tract microbiota in relation to cytokine-, SLPI- and endotoxin levels: application of checkerboard DNA-DNA hybridization (CDH). APMIS. 2008 Apr;116(4):263-77. doi: 10.1111/j.1600-0463.2008.00808.x.
7 Impact of Standard Bacterial Vaginosis Treatment on the Genital Microbiota, Immune Milieu, and Ex Vivo Human Immunodeficiency Virus Susceptibility.Clin Infect Dis. 2019 May 2;68(10):1675-1683. doi: 10.1093/cid/ciy762.

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