| General Information of MIC (ID: MIC01325) |
| MIC Name |
Treponema pallidum (spirochaetes)
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| MIC Synonyms |
Microspironema pallidum
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| Body Site |
Vagina
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| Lineage |
Kingdom: Bacteria
Phylum: Spirochaetes
Class: Spirochaetia
Order: Spirochaetales
Family: Spirochaetaceae
Genus: Treponema
Species: Treponema pallidum
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| Oxygen Sensitivity |
Microaerophile
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| Microbial Metabolism |
Glycolysis
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| Gram |
Negative
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| Host Relationship |
Pathogen
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| Description |
Treponema pallidum is a Gram-nonreactive spirochete which causes treponemal diseases such as syphilis.
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| External Links |
Taxonomy ID |
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| Genome Assembly ID |
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| GOLD Organism ID |
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| Host Genetic Factors (HGFs) |
| AMY1A |
| HGF ID |
HGF2311 |
HGF Info
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Class |
Copy Number Variation: Gene Duplication (CNV-GDu) |
| Description |
Oral microbiome Treponema differs between high AMY1-CN and low AMY1-CN groups at the OTU level (p-value<0.05). |
[1] |
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| Host Immune Factors (HIFs) |
| C-X-C motif chemokine 9 |
| HIF ID |
HIFM0073 |
HIF Info
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Class |
Cytokine (Cyt) |
| Description |
Treponema is the gingivitis biomarker in the MiG(Cxcl9) model, were among the major donors of flagellar biosynthesis pathways in the plaque microbiota of periodontal disease. |
[2] |
| Interleukin-1 beta |
| HIF ID |
HIFM0138 |
HIF Info
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Class |
Cytokine (Cyt) |
| Description |
Treponema pallidum-induced macrophages induced NLRP3-dependent IL-1beta secretion. |
[3] |
| Macrophages |
| HIF ID |
HIFC0020 |
HIF Info
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Class |
Macrophages (Mac) |
| Description |
The P2X7 receptor promotes phagocytosis in the macrophage response to Treponema pallidum. |
[3] |
| NACHT, LRR and PYD domains-containing protein 3 |
| HIF ID |
HIFM0180 |
HIF Info
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Class |
Nod-like receptor (NLR) |
| Description |
Treponema pallidum-induced macrophages induced NLRP3-dependent IL-1beta secretion. |
[3] |
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| Environmental Factor(s) |
| Disbiome ID |
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| gutMDisorder ID |
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| References |
| 1 |
Human Salivary Amylase Gene Copy Number Impacts Oral and Gut Microbiomes.Cell Host Microbe. 2019 Apr 10;25(4):553-564.e7. doi: 10.1016/j.chom.2019.03.001.
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| 2 |
Predictive modeling of gingivitis severity and susceptibility via oral microbiota.ISME J. 2014 Sep;8(9):1768-80. doi: 10.1038/ismej.2014.32. Epub 2014 Mar 20.
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| 3 |
The P2X7 receptor mediates NLRP3-dependent IL-1 secretion and promotes phagocytosis in the macrophage response to Treponema pallidum. Int Immunopharmacol. 2020 Mar 6;82:106344. doi: 10.1016/j.intimp.2020.106344. Online ahead of print.
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