Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00127)
MIC Name Bacillus firmus (firmicutes)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Bacillaceae
Genus: Bacillus
Species: Bacillus firmus
Oxygen Sensitivity Aerobe
Microbial Metabolism Respiratory
Gram Positive
Genome Size (bp) 4717984
No. of Coding Genes 4511
No. of Non-Coding Genes 87
No. of Small Non-Coding Genes 87
No. of Gene Transcripts 4598
No. of Base Pairs 4717984
Description Bacillus firmus is a species of aerobic, Gram-positive, long, spore-forming rods bacteria within the genus Bacillus.
External Links Taxonomy ID
1399
Genome Assembly ID
ASM103875v1
GOLD Organism ID
Go0086635
Disease Relevance
          Autism spectrum disorder  [ICD-11: 6A02]
             Description Bacilli was associated with autism spectrum disorder. [1]
          Irritable bowel syndrome  [ICD-11: DD91]
             Description Numbers of Bacilli reduced in irritable bowel syndrome than control. [2]
          Pneumonia  [ICD-11: CA40]
             Description Gram-negative bacilli was associated with pneumonia. [3]
Host Genetic Factors (HGFs)
          rs7646786
             HGF ID HGF2087 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs7646786 SNP was significantly associated with the abundance of Bacilli (p-value=2.29E-8). [4]
          rs7083345
             HGF ID HGF1602 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7083345 SNP was significantly associated with the abundance of Bacilli (p-value=3.38E-10). [4]
          rs479105
             HGF ID HGF1252 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs479105 SNP was significantly associated with the abundance of Bacilli (p-value=1.21E-8). [4]
          rs2071199
             HGF ID HGF1738 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2071199 SNP was significantly associated with the abundance of Bacilli (p-value=1.24E-8). [4]
          rs148330122
             HGF ID HGF1354 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs148330122 SNP was significantly associated with the abundance of Bacilli (p-value=1.32E-9). [4]
          rs10928827
             HGF ID HGF2141 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs10928827 SNP was significantly associated with the abundance of Bacilli (p-value=1.02E-8). [4]
Host Immune Factors (HIFs)
          C-X-C motif chemokine 1
             HIF ID HIFM0109 HIF Info       Class Cytokine (Cyt)
             Description The abundance of Bacilli was associated with the CXCL-1 expression. [5]
          Interleukin-17A
             HIF ID HIFM0134 HIF Info       Class Cytokine (Cyt)
             Description Bacilli is associated with IL-17 expression. [5]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Bacilli is associated with IL-1beta expression. [5]
          Immunoglobulin M
             HIF ID HIFM0266 HIF Info       Class Immunoglobulin (Ig)
             Description Bacillus firmus can stimulate the formation of immunoglobulin M(IgM). [6]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Bacillus firmus can stimulate the formation of immunoglobulin A(IgA). [6]
          T cells
             HIF ID HIFC0002 HIF Info       Class T cells (TCs)
             Description Bacillus firmus was a strong polyclonal activator of B lymphocytes that was the most efficient in stimulating the formation of immunoglobulins of all classes, in particular IgM and IgA. [6]
Environmental Factor(s)
             Disbiome ID
      125
             gutMDisorder ID
      gm0067
References
1 Alterations in Gut Glutamate Metabolism Associated with Changes in Gut Microbiota Composition in Children with Autism Spectrum Disorder. mSystems. 2019 Jan 29;4(1):e00321-18. doi: 10.1128/mSystems.00321-18. eCollection 2019 Jan-Feb.
2 The gut microbiota and irritable bowel syndrome: friend or foe. Int J Inflam. 2012;2012:151085. doi: 10.1155/2012/151085. Epub 2012 Apr 22.
3 Viruses and Gram-negative bacilli dominate the etiology of community-acquired pneumonia in Indonesia, a cohort study. Int J Infect Dis. 2015 Sep;38:101-7. doi: 10.1016/j.ijid.2015.07.023. Epub 2015 Aug 6.
4 Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.Nat Genet. 2016 Nov;48(11):1396-1406. doi: 10.1038/ng.3695. Epub 2016 Oct 10.
5 Cording Mycobacterium tuberculosis Bacilli Have a Key Role in the Progression towards Active Tuberculosis, Which is Stopped by Previous Immune Response. Microorganisms. 2020 Feb 8;8(2):228. doi: 10.3390/microorganisms8020228.
6 Effect of Bacillus firmus and other sporulating aerobic microorganisms on in vitro stimulation of human lymphocytes. A comparative study. Folia Microbiol (Praha). 1994;39(6):501-4. doi: 10.1007/BF02814071.

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