Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00052)
MIC Name Aggregatibacter aphrophilus (gamma-proteobacteria)
MIC Synonyms Haemophilus aphrophilus
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pasteurellales
Family: Pasteurellaceae
Genus: Aggregatibacter
Species: Aggregatibacter aphrophilus
Oxygen Sensitivity Aerobe
Microbial Metabolism Respiratory
Gram Negative
Genome Size (bp) 2414427
No. of Coding Genes 2098
No. of Non-Coding Genes 77
No. of Small Non-Coding Genes 77
No. of Gene Transcripts 2175
No. of Base Pairs 2414427
Description Aggregatibacter aphrophilus (formerly Haemophilus aphrophilus) is an aerobic Gram-negative coccobacillus. It is classically associated with infective endocarditis. Other infections reported in the literature include brain abscess, bone and joint infections and endophthalmitis.
External Links Taxonomy ID
732
Genome Assembly ID
ASM126203v1
GOLD Organism ID
Go0001493
Disease Relevance
          Diseases of mediastinum  [ICD-11: GB22]
             Description Aggregatibacter aphrophilus was associated with mediastinitis. [1]
          Empyema  [ICD-11: CA44]
             Description Aggregatibacter aphrophilus is associated with empyema. [2]
          Endophthalmitis  [ICD-11: 9C21]
             Description Aggregatibacter aphrophilus is associated with endophthalmitis. [3]
          Infectious endocarditis  [ICD-11: BB40]
             Description Aggregatibacter aphrophilus is classically associated with infective endocarditis. [4]
          Intracranial abscess  [ICD-11: 1D03]
             Description Aggregatibacter aphrophilus is associated with brain abscess. [5]
          Meningococcal disease  [ICD-11: 1C1C]
             Description Aggregatibacter was associated with bacteraemia. [6]
          Obesity  [ICD-11: 5B81]
             Description Aggregatibacter aphrophilus was associated with genetic variants in Obesity. [7]
          Osteomyelitis or osteitis  [ICD-11: FB84]
             Description Aggregatibacter aphrophilus is associated with bone infection. [8]
          Septic arthritis  [ICD-11: FA10]
             Description Aggregatibacter aphrophilus is associated with joint infection. [9]
Host Genetic Factors (HGFs)
          rs17740079
             HGF ID HGF1606 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs17740079 SNP was significantly associated with the abundance of Aggregatibacter aphrophilus (p-value<1.00E-08). [10]
          rs4434138
             HGF ID HGF1312 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs4434138 SNP was associated with the abundance of Aggregatibacter (p-value=1.17E-05). [11]
          rs2276014
             HGF ID HGF1797 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The rs2276014 SNP was associated with the abundance of Aggregatibacter (p-value=1.12E-05). [11]
          rs13621
             HGF ID HGF1449 HGF Info       Class Single Nucleotide Polymorphism: Downstream variant (SNP-DV)
             Description The rs13621 SNP was associated with the abundance of Aggregatibacter (p-value=1.05E-05). [11]
          rs13081014
             HGF ID HGF1386 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs13081014 SNP was significantly associated with the relative abundance of Aggregatibacter (p-value=4.97E-08). [12]
Host Immune Factors (HIFs)
          C-C motif chemokine 2
             HIF ID HIFM0022 HIF Info       Class Cytokine (Cyt)
             Description At the genus level, Aggregatibacter is associated with the CCL2 expression. [13]
          C-X-C motif chemokine 1
             HIF ID HIFM0109 HIF Info       Class Cytokine (Cyt)
             Description At the genus level, Aggregatibacter is associated with CXCL1 expression. [13]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Aggregatibacter is associated with IL-6 expression. [13]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description Aggregatibacter is associated with IL-8 expression. [13]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Aggregatibacter is associated with the level of TNF-Alpha. [13]
Environmental Factor(s)
             Disbiome ID
      435
References
1 Exceptional association of two species of bacteria causing mediastinitis: Haemophilus influenzae (H. influenzae) and Aggregatibacter aphrophilus (A. aphrophilus). BMC Infect Dis. 2018 Aug 16;18(1):407. doi: 10.1186/s12879-018-3269-4.
2 Heterotopic ossification after patellar tendon repair in a man with trisomy 8 mosaicism: a case report and literature review. J Med Case Rep. 2011 Sep 12;5:453. doi: 10.1186/1752-1947-5-453.
3 Compound double ileoileal and ileocecocolic intussusception caused by lipoma of the ileum in an adult patient: A case report. J Med Case Rep. 2011 Sep 12;5:452. doi: 10.1186/1752-1947-5-452.
4 Aggregatibacter aphrophilus in a patient with recurrent empyema: a case report. J Med Case Rep. 2011 Sep 12;5:448. doi: 10.1186/1752-1947-5-448.
5 Changes in physiological tremor associated with an epileptic seizure: a case report. J Med Case Rep. 2011 Sep 12;5:449. doi: 10.1186/1752-1947-5-449.
6 Incidence of HACEK bacteraemia in Denmark: A 6-year population-based study. Int J Infect Dis. 2018 Mar;68:83-87. doi: 10.1016/j.ijid.2018.01.025. Epub 2018 Feb 1.
7 M-GWAS for the gut microbiome in Chinese adults illuminates on complex diseases. bioRxiv, 2019.
8 A case of polyarteritis nodosa limited to the right calf muscles, fascia, and skin: a case report. J Med Case Rep. 2011 Sep 12;5:450. doi: 10.1186/1752-1947-5-450.
9 Contribution of magnetic resonance imaging in the diagnosis of talus skip metastases of Ewing's sarcoma of the calcaneus in a child: a case report. J Med Case Rep. 2011 Sep 12;5:451. doi: 10.1186/1752-1947-5-451.
10 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
11 Host genetic variation impacts microbiome composition across human body sites.Genome Biol. 2015 Sep 15;16(1):191. doi: 10.1186/s13059-015-0759-1.
12 Association of host genome with intestinal microbial composition in a large healthy cohort.Nat Genet. 2016 Nov;48(11):1413-1417. doi: 10.1038/ng.3693. Epub 2016 Oct 3.
13 Commensal and pathogenic biofilms differently modulate peri-implant oral mucosa in an organotypic model. Cell Microbiol. 2019 Oct;21(10):e13078. doi: 10.1111/cmi.13078. Epub 2019 Jul 17.

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