Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00758)
MIC Name Leptospira borgpetersenii (spirochaetes)
Body Site Blood
Lineage Kingdom: Bacteria
Phylum: Spirochaetes
Class: Spirochaetia
Order: Leptospirales
Family: Leptospiraceae
Genus: Leptospira
Species: Leptospira borgpetersenii
Oxygen Sensitivity Aerobe
Microbial Metabolism Asaccharolytic; Utilize oxygen as electron receptor
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 3931782
Description Leptospira borgpetersenii is a species of aerobic, Gram negative, motile bacteria with a spiral shape. It is a bacterial pathogen of cattle and it also causes zoonotic infections in humans. It is important because it poses a significant public health problem because leptospirosis causes organ failure in the liver, lungs, kidney, and brain.
External Links Taxonomy ID
174
Genome Assembly ID
ASM985809v1
GOLD Organism ID
Go0501922
Host Immune Factors (HIFs)
          Interferon-4
             HIF ID HIFM0149 HIF Info       Class Cytokine (Cyt)
             Description Leptospira borgpetersenii is associated with IL-4 expression. [1]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description The abundance of Leptospira borgpetersenii is associated with TNF-Alpha. [1]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description The abundance of Leptospira borgpetersenii is associated with IFN-Gamma. [1]
          Interleukin-1
             HIF ID HIFM0263 HIF Info       Class Cytokine (Cyt)
             Description The abundance of Leptospira borgpetersenii is associated with IL-1. [1]
          CD4+ helper T cells
             HIF ID HIFC0068 HIF Info       Class T cells (TCs)
             Description Th1 cells developed an adaptive immune response by production of IgG2 antigen-specific antibodies following Leptospira borgpetersenii infection. [1]
          CD4+ T cells
             HIF ID HIFC0069 HIF Info       Class T cells (TCs)
             Description CD4 T lymphocytes produced the majority of IFN-gamma after Leptospira borgpetersenii infection. [1]
          Toll-like receptor
             HIF ID HIFM0001 HIF Info       Class Toll-like receptor (TLR)
             Description Toll-like receptors were involved in the protection against pathogenic Leptospira antigens. [2]
          Toll-like receptor 2
             HIF ID HIFM0217 HIF Info       Class Toll-like receptor (TLR)
             Description Leptospira borgpetersenii is associated with TLR2 expression. [1]
Environmental Factor(s)
             Disbiome ID
      69
             gutMDisorder ID
      gm0421
References
1 Evaluation of type 1 immune response in naive and vaccinated animals following challenge with Leptospira borgpetersenii serovar Hardjo: involvement of WC1(+) gammadelta and CD4 T cells. Infect Immun. 2002 Nov;70(11):6147-57. doi: 10.1128/iai.70.11.6147-6157.2002.
2 Leptospira and inflammation. Mediators Inflamm. 2012;2012:317950. doi: 10.1155/2012/317950. Epub 2012 Oct 21.

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