Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFC0004)
HIF Name
Monocyte-derived dendritic cells
HIF Synonym(s)
moDCs, Monocyte-derived dendritic cells
HIF Classification
Dendritic cells (DCs)
Description Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expands during cancer, inflammation and infection, and that has a remarkable ability to suppress T-cell responses. [1]
Microbe Species (MIC) Regulated by This HIF
         Methanobrevibacter smithii (euryarchaeotes) MIC00792
             Description Methanobrevibacter smithii which is associated with monocyte-derived dendritic cells response. [2]
         Methanomassiliicoccus luminyensis (euryarchaeotes) MIC00800
             Description Stimulation with Methanomassiliicoccus luminyensis can lead to the release of pro-inflammatory cytokines TNF-alpha and IL-1beta in moDCs. [3]
         Porphyromonas gingivalis (CFB bacteria) MIC01000
             Description Expression of Porphyromonas gingivalis mfa1 fimbriae was increased in Monocyte-derived dendritic cells of periodontitis patients. [4]
References
1 Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol. 2009 Mar;9(3):162-74. doi: 10.1038/nri2506.
2 The intestinal archaea Methanosphaera stadtmanae and Methanobrevibacter smithii activate human dendritic cells. PLoS One. 2014 Jun 10;9(6):e99411. doi: 10.1371/journal.pone.0099411. eCollection 2014.
3 Immunogenic properties of the human gut-associated archaeon Methanomassiliicoccus luminyensis and its susceptibility to antimicrobial peptides. PLoS One. 2017 Oct 5;12(10):e0185919. doi: 10.1371/journal.pone.0185919. eCollection 2017.
4 Polymicrobial synergy within oral biofilm promotes invasion of dendritic cells and survival of consortia members.NPJ Biofilms Microbiomes. 2019 Mar 18;5:11. doi: 10.1038/s41522-019-0084-7. eCollection 2019.

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