Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01112)
MIC Name Rikenella microfusus (CFB bacteria)
MIC Synonyms Bacteroides microfusus
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Rikenellaceae
Genus: Rikenella
Species: Rikenella microfusus
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Fermentative
Gram Negative
Description Rikenella microfusus is an obligately anaerobic, Gram-negative bacterium.
External Links Taxonomy ID
28139
Genome Assembly ID
52683_E03
GOLD Organism ID
Go0500249
Disease Relevance
          Graves disease  [ICD-11: 5A02]
             Description Rikenellaceae were significantly low in the Graves' disease group as compared to control. [1]
Host Genetic Factors (HGFs)
          ARNTL
             HGF ID HGF2325 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of BMAL1 could increase relative abundances of Rikenella (p-value<0.05). [2]
          KLB
             HGF ID HGF2334 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of KLB increased the proportion of Rikenella. [3]
          TLR5
             HGF ID HGF2330 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The TLR5 was significantly associated with the decreased abundance of Rikenellaceae (p-value<0.05). [4]
          SLC15A1
             HGF ID HGF2354 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of PepT1 could increase the abundance of Rikenellaceae. [5]
          rs571312
             HGF ID HGF2159 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The variant gene MC4R of innate immunity rs571312 is significantly associated with the abundance of gut micriobiota Rikenellaceae (p-value=0.0122). [6]
Host Immune Factors (HIFs)
          T-lymphocyte activation antigen CD86
             HIF ID HIFM0055 HIF Info       Class Checkpoint molecule (CM)
             Description The proportions of cells expressing the co-receptors CD86 was associated with Rikenellaceae. [7]
          T-cell immunoreceptor with Ig and ITIM domains
             HIF ID HIFM0214 HIF Info       Class Checkpoint molecule (CM)
             Description The expression of co-receptors TIGIT was associated with Rikenellaceae families. [7]
          Tumor necrosis factor receptor superfamily member 4
             HIF ID HIFM0231 HIF Info       Class Checkpoint molecule (CM)
             Description The proportions of cells expressing the co-receptors OX40 was associated with Rikenellaceae families. [8]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Rikenellaceae gen.was significantly enriched in the IgA (Low or no IgA binding) consortia. [9]
          CD4+ regulatory T cells
             HIF ID HIFC0034 HIF Info       Class T cells (TCs)
             Description Rikenellaceae is associated with CD4+ T cells responses. [10]
          CD8+ T cells
             HIF ID HIFC0073 HIF Info       Class T cells (TCs)
             Description Rikenellaceae is associated with CD8+ T cells responses. [10]
Environmental Factor(s)
             Disbiome ID
      381
References
1 Molecular Alteration Analysis of Human Gut Microbial Composition in Graves' disease Patients. Int J Biol Sci. 2018 Sep 7;14(11):1558-1570. doi: 10.7150/ijbs.24151. eCollection 2018.
2 Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock.Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10479-84. doi: 10.1073/pnas.1501305112. Epub 2015 Aug 3.
3 -Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue.JCI Insight. 2017 Apr 20;2(8):e91809. doi: 10.1172/jci.insight.91809. eCollection 2017 Apr 20.
4 Deletion of the Toll-Like Receptor 5 Gene Per Se Does Not Determine the Gut Microbiome Profile That Induces Metabolic Syndrome: Environment Trumps Genotype.PLoS One. 2016 Mar 7;11(3):e0150943. doi: 10.1371/journal.pone.0150943. eCollection 2016.
5 Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations.NPJ Biofilms Microbiomes. 2020 Jul 21;6(1):27. doi: 10.1038/s41522-020-0137-y.
6 Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
7 Exopolysaccharide Produced by Lactobacillus Plantarum Induces Maturation of Dendritic Cells in BALB/c Mice.PLoS One. 2015 Nov 24;10(11):e0143743. doi: 10.1371/journal.pone.0143743. eCollection 2015.
8 Pembrolizumab for anaplastic thyroid cancer: a case study.Cancer Immunol Immunother. 2019 Dec;68(12):1921-1934. doi: 10.1007/s00262-019-02416-7. Epub 2019 Oct 22.
9 IgA Function in Relation to the Intestinal Microbiota.Annu Rev Immunol. 2018 Apr 26;36:359-381. doi: 10.1146/annurev-immunol-042617-053238. Epub 2018 Jan 26.
10 Gut Microbiome, Short-Chain Fatty Acids, and Mucosa Injury in Young Adults with Human Immunodeficiency Virus Infection. Dig Dis Sci. 2019 Jul;64(7):1830-1843. doi: 10.1007/s10620-018-5428-2. Epub 2018 Dec 17.

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