Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0231)
HIF Name
Tumor necrosis factor receptor superfamily member 4
HIF Synonym(s)
Tnfrsf4, OX40 antigen, CD134, OX40L receptor, Txgp1, OX40
HIF Classification
Checkpoint molecule (CM)
Molecular Function
Host cell receptor for virus entry; Receptor
Description OX40 is expressed on T cells to regulate responses to self-proteins. [1]
Pfam TNFR/NGFR cysteine-rich region (PF00020 )
Pathway Cytokine-cytokine receptor interaction (hsa04060 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
TNR4_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Bacteroides sp. (CFB bacteria) MIC00176
             Description The proportions of cells expressing the co-receptors OX40 was associated with Bacteroidales. [2]
         Rikenella microfusus (CFB bacteria) MIC01112
             Description The proportions of cells expressing the co-receptors OX40 was associated with Rikenellaceae families. [2]
References
1 Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy.Clin Cancer Res. 2013 Sep 15;19(18):4917-24. doi: 10.1158/1078-0432.CCR-12-1972. Epub 2013 Jul 18.
2 Pembrolizumab for anaplastic thyroid cancer: a case study.Cancer Immunol Immunother. 2019 Dec;68(12):1921-1934. doi: 10.1007/s00262-019-02416-7. Epub 2019 Oct 22.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.