Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0214)
HIF Name
T-cell immunoreceptor with Ig and ITIM domains
HIF Synonym(s)
TIGIT
HIF Classification
Checkpoint molecule (CM)
Description TIGIT is reported to be crucial immune modulator. [1]
Pfam Immunoglobulin V-set domain (PF07686 )
Pathway Cell adhesion molecules (CAMs) (hsa04514 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
TIGIT_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Bacteroides sp. (CFB bacteria) MIC00176
             Description The expression of co-receptors TIGIT was associated with Bacteroidales. [2]
         Fusobacterium nucleatum (fusobacteria) MIC00617
             Description The colon cancer-associated bacterium Fusobacterium nucleatum may directly inhibit antitumor immunity by engaging TIGIT. [3]
         Rikenella microfusus (CFB bacteria) MIC01112
             Description The expression of co-receptors TIGIT was associated with Rikenellaceae families. [2]
References
1 Exploration of a novel prognostic risk signatures and immune checkpoint molecules in endometrial carcinoma microenvironment.Genomics. 2020 Sep;112(5):3117-3134. doi: 10.1016/j.ygeno.2020.05.022. Epub 2020 May 29.
2 Exopolysaccharide Produced by Lactobacillus Plantarum Induces Maturation of Dendritic Cells in BALB/c Mice.PLoS One. 2015 Nov 24;10(11):e0143743. doi: 10.1371/journal.pone.0143743. eCollection 2015.
3 Cancer and the microbiota.Science. 2015 Apr 3;348(6230):80-6. doi: 10.1126/science.aaa4972.

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