Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00980)
MIC Name Peptostreptococcus anaerobius (firmicutes)
MIC Synonyms Streptococcus anaerobius
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Peptostreptococcaceae
Genus: Peptostreptococcus
Species: Peptostreptococcus anaerobius
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative; Phenylalanine metabolism; Leucine metabolism
Gram Positive
Genome Size (bp) 1988071
No. of Coding Genes 1936
No. of Non-Coding Genes 11
No. of Small Non-Coding Genes 11
No. of Gene Transcripts 1947
No. of Base Pairs 2019341
Description Peptostreptococcus anaerobius is a Gram-positive anaerobic coccus that is widely distributed in the normal human flora. The organism has also been implicated as a causative agent of several systemic infections, including endocarditis and infections of the genitourinary and gastrointestinal tracts.
External Links Taxonomy ID
1261
Genome Assembly ID
ASM156359v1
GOLD Organism ID
Go0003934
Disease Relevance
          Autism spectrum disorder  [ICD-11: 6A02]
             Description Peptostreptococcus was significantly elevated in autistic children. [1]
          Colorectal cancer  [ICD-11: 2B91]
             Description Levels of Peptostreptococcus anaerobius was increased in human colon tumor tissues and adenomas compared with non-tumor tissues. [2]
          Infectious endocarditis  [ICD-11: BB40]
             Description Peptostreptococcus anaerobius is a gram-positive anaerobic coccus that has been implicated as a causative agent of endocarditis. [3]
          Obesity  [ICD-11: 5B81]
             Description Peptostreptococcus was significantly more abundant in the obesity group compared with the controls. [4]
          Peptic ulcer  [ICD-11: DA61]
             Description Elevated content of Peptostreptococcus occured in peptic ulcer disorders. [5]
Host Genetic Factors (HGFs)
          A2ML1
             HGF ID HGF2326 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The duplication of A2ML1 could increase relative abundances of Peptostreptococcus (p-value<0.05). [6]
Host Immune Factors (HIFs)
          B cells
             HIF ID HIFC0001 HIF Info       Class B cells (BCs)
             Description Relative abundances of Peptostreptococcus anaerobius is associated with B cells response. [7]
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description Levels of IL-10 were upregulated in Peptostreptococcus anaerobius infection. [7]
          Interleukin-23 subunit alpha
             HIF ID HIFM0144 HIF Info       Class Cytokine (Cyt)
             Description IL23A genes was overexpressed and cancer-related bacteria(Peptostreptococcus and Bacteroides fragilis) enriched in the high-risk tumors. [8]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description Peptostreptococcus anaerobius was associated with IFN-gamma. [7]
          AKT Serine Kinase signaling pathway/AKT Threonine Kinase signaling pathway
             HIF ID HIFP0002 HIF Info       Class Signaling pathway (SP)
             Description Peptostreptococcus anaerobius is associated with the activation of Akt signalling. [7]
          Nuclear factor kappa B signaling pathway
             HIF ID HIFP0028 HIF Info       Class Signaling pathway (SP)
             Description Peptostreptococcus anaerobius is associated with the activation of NF-kappaB. [7]
          Phosphoinositide 3 kinase signaling pathway
             HIF ID HIFP0033 HIF Info       Class Signaling pathway (SP)
             Description Peptostreptococcus anaerobius is associated with the activation of PI3K pathway. [7]
Environmental Factor(s)
             Disbiome ID
      25
             gutMDisorder ID
      gm0521
References
1 The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder. Int J Mol Sci. 2019 Apr 29;20(9):2115. doi: 10.3390/ijms20092115.
2 Peptostreptococcus anaerobius Induces Intracellular Cholesterol Biosynthesis in Colon Cells to Induce Proliferation and Causes Dysplasia in Mice. Gastroenterology. 2017 May;152(6):1419-1433.e5. doi: 10.1053/j.gastro.2017.01.009. Epub 2017 Jan 23.
3 Microbiota-targeted maternal antibodies protect neonates from enteric infection. Nature. 2020 Jan;577(7791):543-548. doi: 10.1038/s41586-019-1898-4. Epub 2020 Jan 8.
4 Characterization of the salivary microbiome in people with obesity. PeerJ. 2018 Mar 16;6:e4458. doi: 10.7717/peerj.4458. eCollection 2018.
5 Profiles of Microbial Fatty Acids in the Human Metabolome are Disease-Specific. Front Microbiol. 2011 Jan 20;1:148. doi: 10.3389/fmicb.2010.00148. eCollection 2010.
6 Middle ear microbiome differences in indigenous Filipinos with chronic otitis media due to a duplication in the A2ML1 gene.Infect Dis Poverty. 2016 Nov 1;5(1):97. doi: 10.1186/s40249-016-0189-7.
7 Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity. Nat Microbiol. 2019 Dec;4(12):2319-2330. doi: 10.1038/s41564-019-0541-3. Epub 2019 Sep 9.
8 High-risk Stage III colon cancer patients identified by a novel five-gene mutational signature are characterized by upregulation of IL-23A and gut bacterial translocation of the tumor microenvironment. Int J Cancer. 2020 Apr 1;146(7):2027-2035. doi: 10.1002/ijc.32775. Epub 2019 Nov 27.

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