Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFP0002)
HIF Name	AKT Serine Kinase signaling pathway/AKT Threonine Kinase signaling pathway
HIF Synonym(s)	AKT signaling pathway
HIF Classification	Signaling pathway (SP)
Description	PI3K-Akt Pathway is an intracellular signal transduction pathway that promotes metabolism, proliferation, cell survival, growth and angiogenesis in response to extracellular signals.	[1]

Microbe Species (MIC) Regulated by This HIF
Klebsiella pneumoniae (enterobacteria)		MIC01405
Description	At the species level, Klebsiella pneumoniae is associated with Akt.		[2]
Peptostreptococcus anaerobius (firmicutes)		MIC00980
Description	Peptostreptococcus anaerobius is associated with the activation of Akt signalling.		[3]
Shigella dysenteriae (enterobacteria)		MIC01181
Description	The abundance of Shigella dysenteriae is associated with Akt.		[4]

References
1	Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization.J Immunol. 2017 Feb 1;198(3):1006-1014. doi: 10.4049/jimmunol.1601515.
2	Pseudomonas aeruginosa and Klebsiella pneumoniae Adaptation to Innate Immune Clearance Mechanisms in the Lung. J Innate Immun. 2018;10(5-6):442-454. doi: 10.1159/000487515. Epub 2018 Apr 4.
3	Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity. Nat Microbiol. 2019 Dec;4(12):2319-2330. doi: 10.1038/s41564-019-0541-3. Epub 2019 Sep 9.
4	Differential expression of gastric MUC5AC in colonic epithelial cells: TFF3-wired IL1 /Akt crosstalk-induced mucosal immune response against Shigella dysenteriae infection. J Cell Sci. 2012 Feb 1;125(Pt 3):703-13. doi: 10.1242/jcs.092148.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.