Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFP0033)
HIF Name	Phosphoinositide 3 kinase signaling pathway
HIF Synonym(s)	PI3K, PI3K signaling pathway
HIF Classification	Signaling pathway (SP)
Description	PI3K-Akt Pathway is an intracellular signal transduction pathway that promotes metabolism, proliferation, cell survival, growth and angiogenesis in response to extracellular signals.	[1]

Microbe Species (MIC) Regulated by This HIF
Klebsiella pneumoniae (enterobacteria)		MIC01405
Description	At the species level, Klebsiella pneumoniae is associated with PI3K.		[2]
Peptostreptococcus anaerobius (firmicutes)		MIC00980
Description	Peptostreptococcus anaerobius is associated with the activation of PI3K pathway.		[3]

References
1	Targeting the PI3K signaling pathway in cancer therapy.Expert Opin Ther Targets. 2012 Jan;16(1):121-30. doi: 10.1517/14728222.2011.644788. Epub 2012 Jan 12.
2	Pseudomonas aeruginosa and Klebsiella pneumoniae Adaptation to Innate Immune Clearance Mechanisms in the Lung. J Innate Immun. 2018;10(5-6):442-454. doi: 10.1159/000487515. Epub 2018 Apr 4.
3	Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity. Nat Microbiol. 2019 Dec;4(12):2319-2330. doi: 10.1038/s41564-019-0541-3. Epub 2019 Sep 9.

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