General Information of MIC (ID: MIC00877)
MIC Name	Mycoplasma synoviae (mycoplasmas)
Body Site	Lung
Lineage	Kingdom: Bacteria Phylum: Tenericutes Class: Mollicutes Order: Mycoplasmatales Family: Mycoplasmataceae Genus: Mycoplasma Species: Mycoplasma synoviae
Oxygen Sensitivity	Facultative anaerobe
Microbial Metabolism	Fermentive
Gram	Negative
Description	Mycoplasma synoviae is a member of the mycoplasma genus, which is a Gram-negative parasitic bacterium responsible for causing respiratory tract disease.
External Links	Taxonomy ID	2109
	Genome Assembly ID	ASM96976v1
	GOLD Organism ID	Go0527434

Host Immune Factors (HIFs)
Interferon-6
HIF ID	HIFM0151	HIF Info	Class	Cytokine (Cyt)
Description	Mycoplasma synoviae was able to induce the secretion of IL-6.				[1]
Toll like receptor signaling pathway
HIF ID	HIFP0043	HIF Info	Class	Signaling pathway (SP)
Description	The induction of proinflamatory cytokines as well as iNOS could be a functional consequence of TLR pathway induction through Mycoplasma synoviae PAMPs.				[1]
Nuclear factor kappa B signaling pathway
HIF ID	HIFP0028	HIF Info	Class	Signaling pathway (SP)
Description	Viable Mycoplasma synoviae cells could induce elevated levels of NF-B transcripts in HD11 cells.				[1]
Toll-like receptor 1
HIF ID	HIFM0216	HIF Info	Class	Toll-like receptor (TLR)
Description	The expression of TLR1 and TLR2 were significantly down-regulated after 6 h and 24 h (p < 0.001) with Mycoplasma synoviae infection.				[1]
Toll-like receptor 15
HIF ID	HIFM0246	HIF Info	Class	Toll-like receptor (TLR)
Description	Diacylated lipopeptide from Mycoplasma synoviae mediated TLR15 could induce innate immune responses.				[1]

Environmental Factor(s)
Disbiome ID			90

References
1	Diacylated lipopeptide from Mycoplasma synoviae mediates TLR15 induced innate immune responses. Vet Res. 2013 Oct 17;44(1):99. doi: 10.1186/1297-9716-44-99.

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